The phenotype of macrophages which are not transformed into foam cells in atherogenesis

Electron microscopy and immunohistochemical analysis clarified the phenotype of macrophages that are not transformed into foam cells. It is suggested that cells having such phenotype are involved in the reaction of immune inflammation in fatty streaks and atherosclerotic plaques and participate in p...

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Bibliographic Details
Published in:Atherosclerosis 1996-04, Vol.121 (2), p.245-251
Main Authors: Nagornev, Vladimir A., Maltseva, Svetlana V.
Format: Article
Language:English
Subjects:
Animals
Antibodies, Monoclonal
Aorta - metabolism
Aorta - pathology
Atherogenesis
Autoradiography
Cell Division
Cell Movement
Coronary Artery Disease - immunology
Coronary Artery Disease - metabolism
Coronary Artery Disease - pathology
Coronary Vessels - metabolism
Coronary Vessels - pathology
Cytokines
Cytokines - biosynthesis
Endothelium, Vascular - metabolism
Endothelium, Vascular - ultrastructure
Fatty Acids - metabolism
Foam Cells - immunology
Foam Cells - metabolism
Foam Cells - ultrastructure
Humans
Immunohistochemistry
Macrophage phenotype
Macrophage proliferation
Macrophages - immunology
Macrophages - metabolism
Macrophages - ultrastructure
Mice
Mice, Inbred BALB C
Microscopy, Electron
Middle Aged
Monocytes - immunology
Monocytes - metabolism
Monocytes - ultrastructure
Muscle, Smooth, Vascular - metabolism
Muscle, Smooth, Vascular - ultrastructure
Phenotype
Rabbits
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Description
Summary:Electron microscopy and immunohistochemical analysis clarified the phenotype of macrophages that are not transformed into foam cells. It is suggested that cells having such phenotype are involved in the reaction of immune inflammation in fatty streaks and atherosclerotic plaques and participate in production of cytokines. These macrophages may be derivatives of monocytes/macrophages that proliferate in the subendothelial space of arteries.
ISSN:0021-9150
1879-1484
DOI:10.1016/0021-9150(95)05726-9