The phenotype of macrophages which are not transformed into foam cells in atherogenesis

• Published in: Atherosclerosis 1996-04, Vol.121 (2), p.245-251
• Main Authors: Nagornev, Vladimir A., Maltseva, Svetlana V.
• Format: Article
• Language: English
• Subjects: Animals; Antibodies, Monoclonal; Aorta - metabolism; Aorta - pathology; Atherogenesis; Autoradiography; Cell Division; Cell Movement; Coronary Artery Disease - immunology; Coronary Artery Disease - metabolism; Coronary Artery Disease - pathology; Coronary Vessels - metabolism; Coronary Vessels - pathology; Cytokines; Cytokines - biosynthesis; Endothelium, Vascular - metabolism; Endothelium, Vascular - ultrastructure; Fatty Acids - metabolism; Foam Cells - immunology; Foam Cells - metabolism; Foam Cells - ultrastructure; Humans; Immunohistochemistry; Macrophage phenotype; Macrophage proliferation; Macrophages - immunology; Macrophages - metabolism; Macrophages - ultrastructure; Mice; Mice, Inbred BALB C; Microscopy, Electron; Middle Aged; Monocytes - immunology; Monocytes - metabolism; Monocytes - ultrastructure; Muscle, Smooth, Vascular - metabolism; Muscle, Smooth, Vascular - ultrastructure; Phenotype; Rabbits
• ISSN: 0021-9150; 1879-1484
• DOI: 10.1016/0021-9150(95)05726-9

Electron microscopy and immunohistochemical analysis clarified the phenotype of macrophages that are not transformed into foam cells. It is suggested that cells having such phenotype are involved in the reaction of immune inflammation in fatty streaks and atherosclerotic plaques and participate in production of cytokines. These macrophages may be derivatives of monocytes/macrophages that proliferate in the subendothelial space of arteries.