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Reduced Connexin 43 Expression in High Grade, Human Prostatic Adenocarcinoma Cells

Gap junction-mediated communication is required for normal cellular growth and differentiation. As cancer is thought to be a manifestation of the breakdown of cell-cell communication, with the concomitant loss of growth control, it would be expected that alterations in the primary structure, process...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 1996-10, Vol.227 (1), p.64-69
Main Authors: Tsai, Harold, Werber, John, Davia, Michael O., Edelman, Morris, Tanaka, Kathryn E., Melman, Arnold, Christ, George J., Geliebter, Jan
Format: Article
Language:English
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Summary:Gap junction-mediated communication is required for normal cellular growth and differentiation. As cancer is thought to be a manifestation of the breakdown of cell-cell communication, with the concomitant loss of growth control, it would be expected that alterations in the primary structure, processing, oligomerization or trafficking of connexin (cxn) molecules would have a profound effect on the neoplastic process. Here we a present a preliminary immunohistochemical and molecular analysis of cxn 43 expression in prostatic epithelial cells from resected human tissue. Our data indicate that benign prostatic epithelial cells express cxn 43 protein, but that this expression is diminished in more advanced, anaplastic cancer cells. These data suggest that decreased connexin expression is not involved in the initiation of prostate cancer, but rather occurs during the progression of the disease.
ISSN:0006-291X
1090-2104
DOI:10.1006/bbrc.1996.1468