Field investigations of tularemia in Norway

Abstract In Norway, tularemia is a common disease in small rodent and hare populations, where large outbreaks can be observed. In humans, the yearly number of cases is low, usually less than ten, with peaks up to 44 recorded in recent years. Serological investigations on hunters and healthy school c...

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Published in:FEMS immunology and medical microbiology 1996-03, Vol.13 (3), p.191-195
Main Authors: Berdal, Bjørn P., Mehl, Reidar, Meidell, Nina K., Lorentzen-Styr, Anne-Marie, Scheel, Olaf
Format: Article
Language:English
Subjects:
Acanthamoeba castellanii
Achantamoeba castellanii
Adolescent
Adult
Amoeba
Animals
Antibodies, Bacterial - biosynthesis
Epidemiology
Field investigations
Field tests
Francisella tularensis
Humans
Ingestion
Internalization
Mice
Norway - epidemiology
Protozoa
Rabbits
Rats
Ticks
Tularemia
Tularemia - epidemiology
Virulence
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Summary:Abstract In Norway, tularemia is a common disease in small rodent and hare populations, where large outbreaks can be observed. In humans, the yearly number of cases is low, usually less than ten, with peaks up to 44 recorded in recent years. Serological investigations on hunters and healthy school children nevertheless indicate, with up to 4.7% positivity in the latter group, that Francisella tularensis low-grade infection is widespread. F. tularensis in co-culture with amoebae, e.g. Achantamoeba castellanii, may grow after internalization and kill the amoeba. As with Legionella, Francisella virulence may be enhanced after protozoan ingestion. This suggests a mechanism that can explain the pattern of dissemination and infection in our region.
ISSN:0928-8244
1574-695X
2049-632X
DOI:10.1111/j.1574-695X.1996.tb00235.x