Effects of synthetic form of tracheal antimicrobial peptide on respiratory pathogens

We have synthesized a C-terminal portion of tracheal antimicrobial peptide (TAP) with 38 amino acids and tested it for efficacy on various clinical isolates of Pseudomonas aeruginosa strains from patients with cystic fibrosis and also on Aspergillus fumigatus. Our results indicate that the synthetic...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1996-03, Vol.37 (3), p.599-604
Main Authors: Lawyer, Carl, Pai, Sudha, Watabe, Misako, Bakir, Haithem, Eagleton, Lanie, Watabe, Kounosuke
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents
Anti-Infective Agents - chemical synthesis
Anti-Infective Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antimicrobial Cationic Peptides
Aspergillus fumigatus
Aspergillus fumigatus - drug effects
Aspergillus fumigatus - growth & development
Biological and medical sciences
Cystic Fibrosis - microbiology
Escherichia coli - drug effects
Escherichia coli - growth & development
Humans
Medical sciences
Microbial Sensitivity Tests
Peptide Fragments - chemical synthesis
Peptide Fragments - pharmacology
Peptides - chemical synthesis
Peptides - pharmacology
Pharmacology. Drug treatments
Pseudomonas aeruginosa
Pseudomonas aeruginosa - drug effects
Pseudomonas aeruginosa - growth & development
Respiratory Tract Infections - microbiology
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Summary:We have synthesized a C-terminal portion of tracheal antimicrobial peptide (TAP) with 38 amino acids and tested it for efficacy on various clinical isolates of Pseudomonas aeruginosa strains from patients with cystic fibrosis and also on Aspergillus fumigatus. Our results indicate that the synthetic TAP has both potent bactericidal and fungicidal activities and that a combination of TAP and amphotericin B showed strong additive effects of growth inhibition on A. fumigatus. These results suggest that TAP is potentially an effective therapy for Aspergillus and multi-drug-resistant Pseudomonas, pathogens that are often a serious threat to patients with cystic fibrosis.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/37.3.599