Immunocytochemical detection of isolated epithelial tumor cells in bone marrow of patients with pancreatic carcinoma

Epithelial cells in the bone marrow of 42 patients with pancreatic carcinoma were identified immunocytochemically with monoclonal antibodies directed to epithelial cytokeratins. The occurrence of tumor relapse in patients who underwent complete surgical resection was significantly associated with cy...

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Bibliographic Details
Published in:The American journal of surgery 1996-09, Vol.172 (3), p.297-298
Main Authors: Thorban, Stefan, Roder, Jürgen D., Pantel, Klaus, Rüdiger Siewert, J.
Format: Article
Language:English
Subjects:
Adenocarcinoma - pathology
Adenocarcinoma - secondary
Adenocarcinoma - surgery
Biological and medical sciences
Bone marrow
Bone Marrow - pathology
Cytokeratin
Epithelial cells
Epithelium
Epithelium - chemistry
Epithelium - pathology
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Immunohistochemistry
Keratins - analysis
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Medical sciences
Monoclonal antibodies
Neoplasm Recurrence, Local
Pancreatic cancer
Pancreatic carcinoma
Pancreatic Neoplasms - pathology
Pancreatic Neoplasms - surgery
Prognosis
Prospective Studies
Tumor cells
Tumors
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Description
Summary:Epithelial cells in the bone marrow of 42 patients with pancreatic carcinoma were identified immunocytochemically with monoclonal antibodies directed to epithelial cytokeratins. The occurrence of tumor relapse in patients who underwent complete surgical resection was significantly associated with cytokeratin-positivity in bone marrow. The presence of these cells is indicative of an increased disseminative capability of the primary tumor and defines a new category of patients for neoadjuvant therapy.
ISSN:0002-9610
1879-1883
DOI:10.1016/S0002-9610(96)00103-1