A systematic survey of the intergenic region between the murine oxytocin- and vasopressin-encoding genes

The genomic region between the oxytocin (OT) and vasopressin (VP) genes in the two strains of mice was independently sequenced by our two groups. In this report, we present our collated sequence data and analyses. The mouse intergenic region (MUIGR) was aligned to that of the rat, which has been rep...

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Bibliographic Details
Published in:Gene 1996-09, Vol.174 (1), p.71-78
Main Authors: Ratty, Anil K., Jeong, Seong-Whan, Nagle, James W., Chin, Hemin, Gainer, Harold, Murphy, David, Venkatesh, B.
Format: Article
Language:English
Subjects:
129/SvJ and C57BL/10A mouse strains
Animals
Base Sequence
Cloning, Molecular
Conserved Sequence
Mice
Molecular Sequence Data
Oxytocin - genetics
Repetitive elements
Sequence Alignment
Sequence Analysis, DNA
Transcription factor recognition sequences
Vasopressins - genetics
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Summary:The genomic region between the oxytocin (OT) and vasopressin (VP) genes in the two strains of mice was independently sequenced by our two groups. In this report, we present our collated sequence data and analyses. The mouse intergenic region (MUIGR) was aligned to that of the rat, which has been reported to contain 6.4-kb long interspersed nuclear element (LINE). The MUIGR sequences in the two mice strains did not contain any LINE sequences. This suggests that the approximately 3.5-kb sequence that is conserved between the rat and mouse intergenic regions is likely to be involved in the regulation of OT and VP expression. We also observed several conserved putative transcription factor recognition sequences. Analysis of the MUIGR revealed the lack of any significant ORFs, but the presence of several repetitive elements.
ISSN:0378-1119
1879-0038
DOI:10.1016/0378-1119(96)00370-8