Airway Interleukin-8 in Elderly Patients with Bacterial Lower Respiratory Tract Infections

We investigated the interleukin-8 (IL-8) levels and neutrophil numbers in the sputum of 9 elderly patients with lower respiratory tract infections, including Pseudomonas aeruginosa infection, before and after treatment with various antimicrobial agents. The IL-8 levels in sputum supernatants and the...

Full description

Saved in:
Bibliographic Details
Published in:MICROBIOLOGY and IMMUNOLOGY 1996, Vol.40(2), pp.177-182
Main Authors: Ponglertnapagorn, Preecha, Oishi, Kazunori, Iwagaki, Akitaka, Sonoda, Fuminari, Watanabe, Kiwao, Nagatake, Tsuyoshi, Matsushima, Kouji, Matsumoto, Keizo
Format: Article
Language:English
Subjects:
Aged
Bacteria
Bacterial Infections - immunology
Bacterial lower respiratory tract infections
Bacteriology
Biological and medical sciences
Bronchiectasis - immunology
Bronchitis - immunology
Bronchopneumonia - immunology
Female
Fundamental and applied biological sciences. Psychology
Humans
Interleukin-8
Interleukin-8 - immunology
Interleukin-8 - pharmacology
Male
Microbiology
Middle Aged
Opsonophagocytosis
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
Pneumonia, Bacterial - immunology
Pseudomonas aeruginosa
Pseudomonas aeruginosa - drug effects
Recombinant Fusion Proteins - pharmacology
Respiratory Tract Infections - immunology
Serum Albumin
Sputum - immunology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We investigated the interleukin-8 (IL-8) levels and neutrophil numbers in the sputum of 9 elderly patients with lower respiratory tract infections, including Pseudomonas aeruginosa infection, before and after treatment with various antimicrobial agents. The IL-8 levels in sputum supernatants and the neutrophil numbers in sputum smears from 9 patients decreased significantly after the elimination of the causative respiratory pathogens. We also demonstrated that human recombinant IL-8 at a range of 6.25-25ng/ml significantly enhanced opsonophagocytic killing of P. aeruginosa immunotype-1 strain by human neutrophils in the presence of a serotype-specific anti-lipopolysaccharide monoclonal antibody and fresh normal human serum. These data suggest that the level of IL-8 production in the airways of patients with lower respiratory tract infections is dependent on bacterial densities, and indicate the important role of IL-8 not only in neutrophil migration but also in opsonophagocytic killing of bacteria in the lower respiratory tract.
ISSN:0385-5600
1348-0421
DOI:10.1111/j.1348-0421.1996.tb03322.x