Elevated serum levels of interleukin-12 in chronic progressive multiple sclerosis

The serum levels of the heterodimeric cytokine IL-12 were measured by solid-phase ELISA in a group of healthy subjects, multiple sclerosis (MS) patients with secondary chronic progressive course of the disease and patients suffering from other neurological diseases (OND) Serum levels of IL-12 higher...

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Bibliographic Details
Published in:Journal of neuroimmunology 1996-10, Vol.70 (1), p.87-90
Main Authors: Nicoletti, F., Patti, F., Cocuzza, C., Zaccone, P., Nicoletti, A., Di Marco, R., Reggio, A.
Format: Article
Language:English
Subjects:
Adult
Autoimmune diseases
Chronic Disease
Cytokines
Disease Progression
Enzyme-Linked Immunosorbent Assay
Experimental allergic encephalomyelitis interleukin-12
Female
Humans
Interleukin-12 - blood
Male
Middle Aged
Multiple sclerosis
Multiple Sclerosis - blood
Nervous System Diseases - blood
Single-Blind Method
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Summary:The serum levels of the heterodimeric cytokine IL-12 were measured by solid-phase ELISA in a group of healthy subjects, multiple sclerosis (MS) patients with secondary chronic progressive course of the disease and patients suffering from other neurological diseases (OND) Serum levels of IL-12 higher than 5 pg/ml (limit of sensitivity of the assay) were only found in 2/30 (6.7%) of the healthy subjects and none of the 8 subjects with OND. In contrast, IL-12 was found in the majority of CPMS patients’ sera (10/15, 66.7%) with values ranging between 5.5 and 18.6 pg/ml. These results are suggestive for an up-regulated production of IL-12 in CPMS.
ISSN:0165-5728
1872-8421
DOI:10.1016/S0165-5728(96)00101-4