Human T cell specific proteinase (HuTSP) is encoded by the T cell and natural killer cell specific human Hanukah factor (HuHF) gene

HuTSP, a serine proteinase which is specifically associated with activated T lymphocytes, was purified to homogeneity and characterized. N-terminal amino acid sequencing revealed identity with a sequence predicted from the human Hanukah factor (HF) gene, which was isolated from a human T cell cDNA l...

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Bibliographic Details
Published in:FEBS letters 1988-09, Vol.237 (1), p.45-48
Main Authors: Fruth, Uli, Eckerskorn, Christoph, Lottspeich, Friedrich, Kramer, Michael D., Prester, Marlot, Simon, Markus M.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Cell Line
Enzymes and enzyme inhibitors
Fundamental and applied biological sciences. Psychology
Genes
Granzymes
Human T cell, Murine T cell
Humans
Hydrolases
Killer Cells, Natural - enzymology
Molecular Sequence Data
Molecular Weight
Serine Endopeptidases - genetics
Serine Endopeptidases - isolation & purification
Serine proteinase
T-Lymphocytes - enzymology
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Summary:HuTSP, a serine proteinase which is specifically associated with activated T lymphocytes, was purified to homogeneity and characterized. N-terminal amino acid sequencing revealed identity with a sequence predicted from the human Hanukah factor (HF) gene, which was isolated from a human T cell cDNA library. The dimeric structure of HuTSP, together with its extensive sequence homologies with the murine T cell specific proteinase, MTSP-1, suggests phylogenetic conservation of this serine proteinase family.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(88)80168-6