Determination of Hemoglobin A1C in Normal and Diabetic Mice : Neonatal Streptozotocin-Induced Diabetic Mice and KK-Ay Mice

We have determined Hemoglobin A1C (HbA1C) in normal, neonatal streptozotocin-induced diabetic animals (NSZ), a model of lean-type non-insulin-dependent diabetes mellitus (NIDDM) with hypoinsulinaemia, and KK-Ay mice, a model of obese-type NIDDM with hyperinsulinaemia. The HbA1C of NSZ mice was sligh...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 1996/08/15, Vol.19(8), pp.1078-1079
Main Authors: KITAZAWA, Naoki, MIURA, Toshihiro, KAKO, Mami, USAMI, Masaru, TANIGAWA, Keiichiro, ISHIDA, Hitoshi, SEINO, Yutaka
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Biological and medical sciences
blood glucose
Blood Glucose - analysis
diabetes
Diabetes Mellitus, Experimental - blood
Diabetes Mellitus, Type 2 - blood
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Glycated Hemoglobin A - analysis
hemoglobin A1C
KK-Ay
Male
Medical sciences
Mice
NSZ
Streptozocin
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Summary:We have determined Hemoglobin A1C (HbA1C) in normal, neonatal streptozotocin-induced diabetic animals (NSZ), a model of lean-type non-insulin-dependent diabetes mellitus (NIDDM) with hypoinsulinaemia, and KK-Ay mice, a model of obese-type NIDDM with hyperinsulinaemia. The HbA1C of NSZ mice was slightly increased from 5 to 20 weeks while the HbA1C of KK-Ay mice was markedly increased from 5 to 10 weeks. Our findings showed a difference between experimentally-induced (NSZ) and genetically (KK-Ay) diabetic animals.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.19.1078