Immunomodulatory Properties of Monoclonal Anti-Thy-1.2 Antibody in vivo

Monoclonal mouse anti-Thy-1.2 antibody of IgG3 isotype (MTA) inhibits in a significant and long-term manner the regional graft-versus-host reaction (GVHR) when administered to donors as well as to recipients. The process of sensitization in the reaction of delayed type hypersensitivity to SRBC (DTH)...

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Bibliographic Details
Published in:Immunobiology (1979) 1988-07, Vol.177 (3), p.305-316
Main Authors: Šůla, Karel, Sobotková, Eva, Svobodová, Marie, Nouza, Karel
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic
Animals
Antibodies, Monoclonal
Antibody Formation
Biological and medical sciences
Erythrocytes - immunology
Female
Fibrosarcoma - immunology
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Graft vs Host Reaction
Hypersensitivity, Delayed
Immunobiology
Immunoglobulin G
Isoantibodies
Mice
Mice, Inbred Strains
Modulation of the immune response (stimulation, suppression)
T-Lymphocytes - immunology
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Summary:Monoclonal mouse anti-Thy-1.2 antibody of IgG3 isotype (MTA) inhibits in a significant and long-term manner the regional graft-versus-host reaction (GVHR) when administered to donors as well as to recipients. The process of sensitization in the reaction of delayed type hypersensitivity to SRBC (DTH) is, on the other hand, suppressed only if MTA is administered immediately prior to sensitization. If the time interval between the injection of MTA and of SRBC is extended, the resulting DTH is stimulated. Similarly, the titers of total Ig against SRBC are decreased only if MTA is administered shortly before immunization. Contrasting effects of MTA on the production of IgM and IgG were observed. While the production of IgG was inhibited even after the time interval between the administration of MTA and immunization had been increased, the production of IgM antibodies was stimulated. In recipients of allogeneic Sarcoma I treated with MTA, the primary growth of the tumor is enhanced and the percentage of permanent progressors is increased. Mechanisms of MTA activity are discussed.
ISSN:0171-2985
1878-3279
DOI:10.1016/S0171-2985(88)80049-4