Oestrogen as a calcium channel blocker

This paper reviews the evidence for calcium-antagonist properties of oestrogen which may offer long-term protective effects on the cardiovascular system in postmenopausal women. Oestrogen has already been shown to have a beneficial effect on cholesterol metabolism and deposition, thereby inhibiting...

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Bibliographic Details
Published in:European heart journal 1996-08, Vol.17 (suppl-D), p.27-31
Main Authors: Collins, P., Beale, C. M., Rosano, G. M. C.
Format: Article
Language:English
Subjects:
Animals
Atherosclerosis
calcium antagonism
Calcium Channel Blockers - pharmacology
Calcium Channel Blockers - therapeutic use
cardiovascular disease
Cardiovascular Diseases - physiopathology
Cardiovascular Diseases - prevention & control
Estrogen Replacement Therapy
Estrogens - pharmacology
Estrogens - therapeutic use
Female
Humans
Muscle Relaxation - physiology
Muscle, Smooth, Vascular - drug effects
myocardial ischaemia
oestrogen replacement therapy
post-menopausal women
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Description
Summary:This paper reviews the evidence for calcium-antagonist properties of oestrogen which may offer long-term protective effects on the cardiovascular system in postmenopausal women. Oestrogen has already been shown to have a beneficial effect on cholesterol metabolism and deposition, thereby inhibiting the formation of atherosclerotic plaque and coronary atheroma. Calcium antagonism, resulting in both acute and chronic modulation of coronary and peripheral vasomotion, is another mechanism by which oestrogens may provide cardiovascular benefits to women, including those with existing cardiovascular disease.
ISSN:0195-668X
1522-9645
DOI:10.1093/eurheartj/17.suppl_D.27