N-(2-Hydroxyethyl)phenazinium derivatives of oligonucleotides as effectors of the sequence-specific modification of nucleic acids with reactive oligonucleotide derivatives

It has been found that mono- and especially diphenazinium derivatives of oligonucleotides complementary to the DNA sequence adjacent to the target sequence of the addressed alkylation of DNA, significantly enhance the extent and specificity of alkylation with p-( N-2-chloroethyl- N-methylamino)benzy...

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Bibliographic Details
Published in:FEBS letters 1988-09, Vol.238 (1), p.35-38
Main Authors: Kutyavin, I.V., Podyminogin, M.A., Bazhina, Yu.N., Fedorova, O.S., Knorre, D.G., Levina, A.S., Mamayev, S.V., Zarytova, V.F.
Format: Article
Language:English
Subjects:
Alkylation
Analytical, structural and metabolic biochemistry
Base Sequence
Biological and medical sciences
Dna, deoxyribonucleoproteins
DNA, Single-Stranded - genetics
Effector
Fundamental and applied biological sciences. Psychology
Indicators and Reagents
Molecular Sequence Data
Nucleic acids
Oligonucleotide Probes - chemical synthesis
Phenazines
Phenazinium oligonucleotide derivative
Sequence-specific alkylation
Structure-Activity Relationship
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Summary:It has been found that mono- and especially diphenazinium derivatives of oligonucleotides complementary to the DNA sequence adjacent to the target sequence of the addressed alkylation of DNA, significantly enhance the extent and specificity of alkylation with p-( N-2-chloroethyl- N-methylamino)benzylamide derivatives of the addressing oligonucleotides, thus playing the role of effector of the sequence-specific (complementary addressed) modification.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(88)80220-5