Casein kinase 2 activity increases in the prereplicative phase of liver regeneration

Cytosolic casein kinase activity increased up to 2-fold in the first 6 h after partial hepatectomy and then decreased to control values. This increase was due mainly to casein kinase 2, which reached maximal values at 6–8 h of liver regeneration. In contrast, casein kinase 1 showed a smaller increas...

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Bibliographic Details
Published in:FEBS letters 1988-10, Vol.238 (2), p.273-276
Main Authors: Pérez, Mercè, Grande, Jorge, Itarte, Emilio
Format: Article
Language:English
Subjects:
Analytical, structural and metabolic biochemistry
Animals
Biological and medical sciences
Casein kinase 2
casein kinase II
Casein Kinases
Enzyme Activation - drug effects
Enzymes and enzyme inhibitors
Fundamental and applied biological sciences. Psychology
Glucagon
Glucagon - pharmacology
Hepatectomy
Kinetics
Liver - drug effects
Liver - enzymology
Liver Regeneration
Male
Protein Kinases - metabolism
Protein phosphorylation
Rats
Rats, Inbred Strains
Transferases
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Summary:Cytosolic casein kinase activity increased up to 2-fold in the first 6 h after partial hepatectomy and then decreased to control values. This increase was due mainly to casein kinase 2, which reached maximal values at 6–8 h of liver regeneration. In contrast, casein kinase 1 showed a smaller increase at 4 h and then started to decrease reaching values of about 70% of control at 16 h. The increase in total casein kinase 2 was accompanied with an activation of the enzyme, as determined by the low/high β-casein activity ratio assay. Administration of an acute dose of glucagon to control rats also increased the activity ratio but failed to cause any rise in total casein kinase 2 activity.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(88)80495-2