Bacteremia due to glucose non-fermenting Gram-negative bacilli in patients with hematological neoplasias and solid tumors

• Published in: European journal of clinical microbiology & infectious diseases 1996-07, Vol.15 (7), p.610-615
• Main Authors: MARTINO, R, MARTINEZ, C, PERICAS, R, SALAZAR, R, SOLA, C, BRUNET, S, SUREDA, A, DOMINGO-ALBOS, A
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Alcaligenes; Alcaligenes xylosoxidans; Anti-Bacterial Agents - therapeutic use; Bacteremia - drug therapy; Bacteremia - microbiology; Bacterial diseases; Bacterial sepsis; Biological and medical sciences; Bone Marrow Transplantation - adverse effects; Catheterization - adverse effects; Female; Glucose - metabolism; Gram-Negative Aerobic Bacteria; Gram-Negative Bacterial Infections - microbiology; Hematologic Neoplasms - complications; Hematologic Neoplasms - microbiology; Hematologic Neoplasms - therapy; Hematopoietic Stem Cell Transplantation - adverse effects; Human bacterial diseases; Humans; Infectious diseases; Male; Medical sciences; Microbial Sensitivity Tests; Middle Aged; Neoplasms - complications; Neoplasms - microbiology; Neoplasms - therapy; Neutropenia; Pseudomonas putida; Quinolones - therapeutic use; Retrospective Studies; Sphingomonas paucimobilis; Stenotrophomonas maltophilia; Xanthomonas
• ISSN: 0934-9723; 1435-4373
• DOI: 10.1007/BF01709374

Twenty-six patients with hematological or solid tumors who developed bacteremia caused by Stenotrophomonas maltophilia (n = 10), Pseudomonas putida (n = 6), Sphingomonas paucimobilis complex (n = 4) or Alcaligenes xylosoxidans (n = 6) in the period between 1993 and 1995 were studied. Seventeen patients were neutropenic during the infection, and 13 were undergoing bone marrow or peripheral blood stem cell transplantation. Twenty-three patients had catheter-related infections; only 3 of the 26 patients developed septic complications (all due to Stenotrophomonas maltophilia). Twenty patients were cured following catheter removal, either as primary measure (n = 8) or salvage measure (n = 12). Four responded to antibiotic therapy only, and two died of septic complications. Such infections in hematological and oncological patients have increased in this hospital from no cases in 1975 to 11 cases in 1995.