The role of angiogenic factor bFGF in the development of dural AVFs

Dural arteriovenous fistulas (dAVFs) are known to be acquired disorders. Angiogenic stimulants, such as basic fibroblast growth factor (bFGF), may be involved in the evolution of this disorder. We examined the appearance and localization of bFGF, in human dAVF sinuses, versus a control using immunoh...

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Bibliographic Details
Published in:Acta neurochirurgica 1996-01, Vol.138 (7), p.877-883
Main Authors: Terada, T, Tsuura, M, Komai, N, Higashida, R T, Halbach, V V, Dowd, C F, Wilson, C B, Hieshima, G B
Format: Article
Language:English
Subjects:
Adult
Aged
Arteriovenous Fistula - metabolism
Cerebrovascular Circulation - physiology
Dura Mater - metabolism
Female
Fibroblast Growth Factor 2 - metabolism
Humans
Immunohistochemistry
Male
Middle Aged
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Summary:Dural arteriovenous fistulas (dAVFs) are known to be acquired disorders. Angiogenic stimulants, such as basic fibroblast growth factor (bFGF), may be involved in the evolution of this disorder. We examined the appearance and localization of bFGF, in human dAVF sinuses, versus a control using immunohistochemical techniques, to evaluate these qualitative differences. Four human dural sinuses from dAVF patients, and one control dural sinus were removed at surgery or autopsy and used for this study. Immunohistochemistry for bFGF was performed in all five specimens to identify its appearance and localization. Immunohistochemistry for alpha smooth muscle actin, factor VII related antigen, and macrophage (CD-68) were done in all tissues to identify the bFGF positive cell types. In the control dural sinus, there was negative staining by bFGF immunohistochemistry. However, in all four sinuses of the dAVF patients, smooth muscle cells, endothelial cells, and meningeal cells were stained positively in various degrees by bFGF immunohistochemistry. bFGF may be significant in the development of dAVFs, judging from its strong immunoreactivity in the sinuses of dAVF patients.
ISSN:0001-6268
0942-0940
DOI:10.1007/bf01411267