Lifelong consequences of metabolic adaptations in utero?

Dr. Phillips argues that insulin resistance in adult life may be the price the developing fetus has to pay in return for a short-term successful adaptation to undernutrition in utero. The concept is interesting, and, indeed, challenging. There is, however, a strong need for expansion of the existing...

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Bibliographic Details
Published in:Diabetologia 1996-09, Vol.39 (9), p.1123-1125
Main Author: Eriksson, U J
Format: Article
Language:English
Subjects:
Adult
Animals
Embryonic and Fetal Development
Female
Growth
Humans
Infant, Newborn
Insulin - metabolism
Insulin Resistance
Insulin Secretion
Metabolism
Nutrition Disorders - embryology
Pregnancy
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Summary:Dr. Phillips argues that insulin resistance in adult life may be the price the developing fetus has to pay in return for a short-term successful adaptation to undernutrition in utero. The concept is interesting, and, indeed, challenging. There is, however, a strong need for expansion of the existing knowledge of the possible developmental mechanisms involved, especially against the background of the obvious diagnostic and therapeutic gains in this particular group of patients.
ISSN:0012-186X
1432-0428
DOI:10.1007/BF00400664