Inhibition of Hepatitis B Surface Antigen Secretion on Human Hepatoma Cells. Components from Rubia cordifolia

The antiviral activity in the roots of Rubia cordifolia was examined, and three naphthohydroquinones, furomollugin (1), mollugin (2), and rubilactone (3), were isolated from it. Compounds 1 and 2 strongly suppressed the secretion of hepatitis B surface antigen (HBsAg), both with IC50 = 2.0 μg/mL, in...

Full description

Saved in:
Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1996-03, Vol.59 (3), p.330-333
Main Authors: Ho, Li-Kang, Don, Ming-Jaw, Chen, Hua-Chien, Yeh, Sheau-Farn, Chen, Jau-Ming
Format: Article
Language:English
Subjects:
AGENTES ANTINEOPLASTICOS
Animals
ANTIGENE
ANTIGENOS
ANTIGENS
ANTIMICROBIAL PROPERTIES
ANTINEOPLASTIC AGENTS
Antiviral Agents - chemistry
Antiviral Agents - pharmacology
ANTIVIRAL PROPERTIES
Biological and medical sciences
CELL CULTURE
CELL LINES
CHEMICAL COMPOSITION
COMPOSICION QUIMICA
COMPOSITION CHIMIQUE
CULTIVO DE CELULAS
CULTURE DE CELLULE
DERIVATIVES
Drugs, Chinese Herbal - chemistry
Drugs, Chinese Herbal - pharmacology
ESPECTROMETRIA
FUROMOLLUGIN
General pharmacology
HEP36 CELLS
Hepatitis B Surface Antigens - immunology
HEPATITIS B VIRUS
Humans
INHIBICION
INHIBITION
Liver Neoplasms, Experimental - metabolism
Medical sciences
MEDICAMENT CYTOSTATIQUE
MOLECULAR CONFORMATION
MOLLUGIN
Naphthols - chemistry
Naphthols - isolation & purification
Naphthols - pharmacology
NAPHTHOQUINONE
NEOPLASMAS
NEOPLASME
NEOPLASMS
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
PLANT VIRUSES
PROPIEDADES ANTIMICROBIANAS
PROPRIETE ANTIMICROBIENNE
Pyrans - isolation & purification
Pyrans - pharmacology
Pyrones - chemistry
Pyrones - isolation & purification
Pyrones - pharmacology
QUINONAS
QUINONE
QUINONES
RACINE
RAICES
ROOTS
RUBIA CORDIFOLIA
RUBILACTONE
SECRECION
SECRETION
SPECTRAL ANALYSIS
SPECTROMETRIE
SPECTROMETRY
Tumor Cells, Cultured
VIRUS DE LAS PLANTAS
VIRUS DES VEGETAUX
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The antiviral activity in the roots of Rubia cordifolia was examined, and three naphthohydroquinones, furomollugin (1), mollugin (2), and rubilactone (3), were isolated from it. Compounds 1 and 2 strongly suppressed the secretion of hepatitis B surface antigen (HBsAg), both with IC50 = 2.0 μg/mL, in human hepatoma Hep3B cells while having little effect on the viability of the cells. Evaluation of structurally related derivatives of 1 and 2 revealed that a 6-hydroxy group and a pyran or furan ring contribute to this suppressive effect.
ISSN:0163-3864
1520-6025
DOI:10.1021/np960200h