D3 receptor expression within the basal ganglia is not affected by Parkinson's disease

Quantitative receptor autoradiography and in situ hybridization were used to investigate the expression of dopamine D3 receptors in sections of human brain containing limbic (nucleus accumbens) and striatal (caudate nucleus, putamen) regions. High levels of dopamine D3 receptor mRNA and specific [ 3...

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Bibliographic Details
Published in:Neuroscience letters 1996-08, Vol.214 (2), p.75-78
Main Authors: Hurley, Michael J., Stubbs, Carole M., Jenner, Peter, Marsden, C.David
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Autoradiography
Basal ganglia
Basal Ganglia - drug effects
Basal Ganglia - metabolism
Basal Ganglia - pathology
Biological and medical sciences
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Dopamine Agonists - pharmacology
Dopamine D3 receptor
Female
Humans
In Situ Hybridization
Male
Medical sciences
Middle Aged
Neurology
Oligodeoxyribonucleotides - chemistry
Oligodeoxyribonucleotides - metabolism
Parkinson Disease - metabolism
Parkinson Disease - pathology
Parkinson's disease
Receptor autoradiography
Receptors, Dopamine D2 - biosynthesis
Receptors, Dopamine D3
RNA, Messenger - analysis
RNA, Messenger - biosynthesis
Tetrahydronaphthalenes - pharmacology
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Summary:Quantitative receptor autoradiography and in situ hybridization were used to investigate the expression of dopamine D3 receptors in sections of human brain containing limbic (nucleus accumbens) and striatal (caudate nucleus, putamen) regions. High levels of dopamine D3 receptor mRNA and specific [ 3H](±)7-hydroxy- N,N-di- N-propyl-2-aminotetralin ([ 3H]7-OH-DPAT) binding sites were detected in the nucleus accumbens with lower levels in the caudate nucleus and putamen. No difference in D3 receptor expression was observed between normal and parkinsonian brain. These results indicate that D3 receptor expression is not altered in Parkinson's disease. In addition, they suggest that dopamine release in striatal and limbic areas is not necessary for maintenance of D3 receptor expression.
ISSN:0304-3940
1872-7972
DOI:10.1016/0304-3940(96)12884-6