Neurotransmitter amino acids in cerebrospinal fluid of patients with Parkinson's disease

We measured the CSF and plasma levels of glutamate, glutamine, aspartate (only in plasma), asparagine, glutamine, glycine and GABA in 31 patients with Parkinson's disease and in 45 matched controls. We used an ion-exchange chromatography method. When compared to controls, PD patients had simila...

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Bibliographic Details
Published in:Journal of the neurological sciences 1996-09, Vol.141 (1), p.39-44
Main Authors: Jiménez-Jiménez, Félix Javier, Molina, JoséAntonio, Vargas, Carmela, Gómez, Pilar, Navarro, JoséAntonio, Benito-Leon, Julian, Ortí-Pareja, Miguel, Gasalla, Teresa, Cisneros, Elena, Arenas, Joaquín
Format: Article
Language:English
Subjects:
Aged
Amino Acids - blood
Amino Acids - cerebrospinal fluid
Asparagine - blood
Asparagine - cerebrospinal fluid
Aspartate
Aspartic Acid - blood
Aspartic Acid - cerebrospinal fluid
Biological and medical sciences
Cerebrospinal fluid
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Female
GABA
gamma-Aminobutyric Acid - blood
gamma-Aminobutyric Acid - cerebrospinal fluid
Glutamate
Glutamic Acid - blood
Glutamic Acid - cerebrospinal fluid
Glutamine - blood
Glutamine - cerebrospinal fluid
Glycine
Glycine - blood
Glycine - cerebrospinal fluid
Humans
Male
Medical sciences
Middle Aged
Neurology
Neurotransmitter Agents - blood
Neurotransmitter Agents - cerebrospinal fluid
Neurotransmitter amino acid
Parkinson Disease - blood
Parkinson Disease - cerebrospinal fluid
Parkinson's disease
Plasma
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Summary:We measured the CSF and plasma levels of glutamate, glutamine, aspartate (only in plasma), asparagine, glutamine, glycine and GABA in 31 patients with Parkinson's disease and in 45 matched controls. We used an ion-exchange chromatography method. When compared to controls, PD patients had similar CSF levels of glutamate, glutamine, asparagine, and glycine higher CSF GABA levels higher plasma levels of glutamine, asparagine, and glycine, and lower plasma levels of aspartate. The CSF levels of the amino acids measured were not correlated with the clinical features of PD. Our results that CSF GABA levels are not decreased in PD as previously suggested.
ISSN:0022-510X
1878-5883
DOI:10.1016/0022-510X(96)00115-3