Effects of an electrolytic lesion of the prelimbic area on anxiety-related and cognitive tasks in the rat

• Published in: Behavioural brain research 1996-09, Vol.79 (1), p.51-59
• Main Authors: Maaswinkel, Hans, Gispen, Willem-Hendrik, Spruijt, Berry M.
• Format: Article
• Language: English
• Subjects: Anatomical correlates of behavior; Animals; Anxiety; Anxiety - psychology; Avoidance Learning - physiology; Behavioral psychophysiology; Biological and medical sciences; Cognition - physiology; Electroshock; Elevated plus-maze; Fundamental and applied biological sciences. Psychology; Limbic System - anatomy & histology; Limbic System - physiology; Male; Maze Learning - physiology; Motor Activity - physiology; Open field; Passive avoidance; Prelimbic area; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Rats; Rats, Wistar; Response selection; Shock-prod burying test
• ISSN: 0166-4328; 1872-7549
• DOI: 10.1016/0166-4328(95)00261-8

The aim of this paper was to study the role of the prelimbic area of rats in response selection. A bilateral electrolytic lesion was made in the prelimbic area. The rats were tested in the Morris water-maze, the conditioned shock-prod burying test, the elevated plus-maze, a modified open field test, and the step-through passive avoidance test. In the water-maze during initial acquisition, the latency times of the lesioned rats were not different from those of the controls, but they found the platform faster than the sham-operated rats after the platform was placed in a new position. The lesion did not affect performance in the shock-prod burying test. In the elevated plus-maze the lesioned rats were more active than the sham-operated rats and spent more time on the open arms. In the open field there was no difference between lesioned and sham-operated rats with regard to distance travelled or the time spent near the object in the center of the open field. In the passive avoidance test the lesioned rats had a shorter latency time to enter the shock compartment during the retention trial than the sham-operated rats did. The results were discussed in relation to those of similar studies. The extent and precise localisation of the lesion seems to be crucial for the outcome: lesions confined to the prelimbic area may have the opposite effects of larger lesions. Furthermore, it may well be that the prelimbic area is only involved in processing of stimuli of a specific sensory modality, as made probable by the results of different conditioned reinforcement tasks. Finally, it was stated that we still lack a hypothesis about the precise role of the prelimbic area in response selections.