Bioactive ent-Kaurene Diterpenoids from Annona senegalensis

Activity-guided fractionation of the stem bark of Annona senegalensis gave four bioactive ent-kaurenoids (1−4). Compound 2 showed selective and significant cytotoxicity for MCF-7 (breast cancer) cells (ED50 1.0 μg/mL), and 3 and 4 exhibited cytotoxic selectivity for PC-3 (prostate cancer) cells but...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1996-03, Vol.59 (3), p.301-303
Main Authors: Fatope, Majekodunmi O, Audu, Oladimeji T, Takeda, Yoshio, Zeng, Lu, Shi, Guoen, Shimada, Hiroko, McLaughlin, Jerry L
Format: Article
Language:English
Subjects:
Africa
AGENTES ANTINEOPLASTICOS
Animals
ANNONA SENEGALENSIS
ANTINEOPLASTIC AGENTS
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Artemia
BARK
Biological and medical sciences
CHEMICAL COMPOSITION
COMPOSICION QUIMICA
COMPOSITION CHIMIQUE
CORTEZA
CYTOTOXIC COMPOUNDS
Diterpenes - isolation & purification
Diterpenes - pharmacology
DITERPENOIDE
DITERPENOIDS
DITERPENOS
Drug Screening Assays, Antitumor
ECORCE
ESPECTROMETRIA
General pharmacology
GWANDER DAAJI
Humans
Magnetic Resonance Spectroscopy
MCF-7 (BREAST CANCER) CELLS
Medical sciences
MEDICAMENT CYTOSTATIQUE
MOLECULAR CONFORMATION
MOLECULAR STRUCTURE
NIGERIA
PC-3 (PROSTATE CANCER) CELLS
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plants, Medicinal - chemistry
SPECTRAL ANALYSIS
SPECTROMETRIE
SPECTROMETRY
STEMS
SUBSTANCE TOXIQUE
SUSTANCIAS TOXICAS
TALLO
TIGE
TOXIC SUBSTANCES
Tumor Cells, Cultured
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Summary:Activity-guided fractionation of the stem bark of Annona senegalensis gave four bioactive ent-kaurenoids (1−4). Compound 2 showed selective and significant cytotoxicity for MCF-7 (breast cancer) cells (ED50 1.0 μg/mL), and 3 and 4 exhibited cytotoxic selectivity for PC-3 (prostate cancer) cells but with weaker potencies (ED50 17−18 μg/mL). The structure of the new compound, 3, was deduced from spectral evidence.
ISSN:0163-3864
1520-6025
DOI:10.1021/np9601566