Antigenic and genetic variation of the HN protein of mumps virus strains

National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, UK The relationships between different strains of mumps virus were established by determination of the sequence of the HN gene. They closely resemble those established from other p...

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Bibliographic Details
Published in:Journal of general virology 1996-10, Vol.77 (10), p.2491-2497
Main Authors: Yates, P. J, Afzal, M. A, Minor, P. D
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Antibodies, Monoclonal - immunology
Antibodies, Viral - immunology
Antigenic Variation
Cell Line
Cercopithecus aethiops
Genetic Variation
HN Protein - genetics
HN Protein - immunology
Humans
Mice
Mice, Inbred BALB C
Molecular Sequence Data
mumps virus
Mumps virus - classification
Mumps virus - genetics
Mumps virus - immunology
Mumps virus - isolation & purification
Phylogeny
Vero Cells
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Summary:National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, UK The relationships between different strains of mumps virus were established by determination of the sequence of the HN gene. They closely resemble those established from other portions of the genome, suggesting that the viruses are not recombinants over the areas examined. The relationships were consistent with those established by reaction with monoclonal antibodies raised against the Urabe strain, which has a similar antigenic structure to previously studied laboratory strains, and largely consistent with the specificity of the serological response of naturally infected or vaccinated human subjects. Received 5 June 1996; accepted 2 July 1996.
ISSN:0022-1317
1465-2099
DOI:10.1099/0022-1317-77-10-2491