Studies on the Regulation of Food Intake Using Rat Total Parenteral Nutrition as a Model

OPARA, E. I., M. M. MEGUID, Z.-J. YANG AND W. G. HAMMOND. Studies on the regulation of food intake using rat total parenteral nutrition as a model. NEUROSCI BIOBEHAV REV 20(3)413–443, 1996.—Total parenteral nutrition (TPN) is essential for maintaining the nutritional status of patients who are unabl...

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Published in:Neuroscience and biobehavioral reviews 1996, Vol.20 (3), p.413-443
Main Authors: OPARA, ELIZABETH I, MEGUID, MICHAEL M, ZHONG-JIN, YANG, HAMMOND, WILLIAM G
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Central nervous system
Dopamine
Eating - physiology
Feeding Behavior - physiology
Feeding. Feeding behavior
Food intake
Fundamental and applied biological sciences. Psychology
Hypothalamus
Interleukin-1
Lateral hypothalamus
Models, Biological
Parenteral Nutrition, Total
Rats
Serotonin
Total parenteral nutrition
Tumor necrosis factor
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:OPARA, E. I., M. M. MEGUID, Z.-J. YANG AND W. G. HAMMOND. Studies on the regulation of food intake using rat total parenteral nutrition as a model. NEUROSCI BIOBEHAV REV 20(3)413–443, 1996.—Total parenteral nutrition (TPN) is essential for maintaining the nutritional status of patients who are unable to eat sufficiently to meet their metabolic needs. However, TPN suppresses appetite and ultimately diminishes food intake. Theories concerning the role(s) of peripheral metabolites as signals, acting via the liver and the hypothalamus, for the metabolic control of food intake, have been put forward to explain the anorectic effect of TPN. In addition, it is postulated that changes in peripheral metabolites during TPN may be translated into changes in the levels of brain neurotransmitters known to decrease food intake. This review summarizes studies concerning the effect of TPN on food intake. These studies have involved: (1) characterizing the changes in feeding activity due to TPN; (2) investigating the involvement of the central nervous system; and (3) investigating the role of the periphery and its metabolites in the regulation of food intake during TPN. Some insight into the mechanism of action of TPN on food intake is provided. Copyright © 1996 Elsevier Science Ltd.
ISSN:0149-7634
1873-7528
DOI:10.1016/0149-7634(95)00027-5