Chronic intermittent salt loading enhances functional recovery from polydipsia and survival of vasopressinergic cells in the hypothalamic supraoptic nucleus following transection of the hypophysial stalk

Hypophysial stalk-transected (ST) and sham-operated animals were subjected to a chronic intermittent salt loading regimen (CISL) for 14 days beginning 1 day post surgery (dps). Animals were sacrificed at 15 and 36 dps. Three days after the termination of CISL, water consumption in ST + CISL animals...

Full description

Saved in:
Bibliographic Details
Published in:Brain research 1996-09, Vol.732 (1), p.95-105
Main Authors: Yong-San, Huang, Dellmann, H.Dieter
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
Arginine Vasopressin - analysis
Axons - physiology
Axons - ultrastructure
Biological and medical sciences
Cell Survival
Drinking Behavior
Fundamental and applied biological sciences. Psychology
Hormones and neuropeptides. Regulation
Hyperosmotic stress
Hypophysial stalk transection
Hypothalamo-neurohypophysial system
Hypothalamus - cytology
Hypothalamus - physiology
Hypothalamus. Hypophysis. Epiphysis. Urophysis
Immunohistochemistry
Male
Median Eminence - cytology
Median Eminence - physiology
Neurons - cytology
Neurons - physiology
nucleus
Pituitary Gland - physiology
Polydipsia
Rats
Reference Values
Sodium, Dietary
Supraoptic
Supraoptic Nucleus - cytology
Supraoptic Nucleus - physiology
Thirst
Time Factors
Vasopressin
Vertebrates: endocrinology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Hypophysial stalk-transected (ST) and sham-operated animals were subjected to a chronic intermittent salt loading regimen (CISL) for 14 days beginning 1 day post surgery (dps). Animals were sacrificed at 15 and 36 dps. Three days after the termination of CISL, water consumption in ST + CISL animals decreased to the same level as that of sham-operated animals, while that of ST + water animals was maintained at a significantly higher level. The number of the surviving vasopressinergic neurons in the supraoptic nuclei of the ST + CISL group was significantly higher than that of ST + water group. CISL induced vasopressinergic axonal sprouting into the external zone of the median eminence, and formation of subependymal perivascular plexus. While CISL also enhanced regeneration of oxytocinergic axons into the external zone, it did not, however, have any effect on the number of oxytocinergic neurons surviving axotomy.
ISSN:0006-8993
1872-6240
DOI:10.1016/0006-8993(96)00495-7