Long-term potentiation in the in vitro perirhinal cortex displays associative properties

Brief high frequency tetanization trains reliably induced input-specific long-term potentiation (LTP) in slices of rat perirhinal cortex maintained in vitro. Furthermore, associative interactions between inputs were observed following simultaneous tetanization of separate inputs. This associativity...

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Bibliographic Details
Published in:Brain research 1996-09, Vol.733 (2), p.297-300
Main Author: Bilkey, David K.
Format: Article
Language:English
Subjects:
2-Amino-5-phosphonovalerate - pharmacology
Animals
Association Learning
Associative
Behavioral psychophysiology
Biological and medical sciences
Brain Mapping
Cerebral Cortex - drug effects
Cerebral Cortex - physiology
Electric Stimulation
Electrophysiology
Fundamental and applied biological sciences. Psychology
Limbic System - drug effects
Limbic System - physiology
Long-term potentiation
Long-Term Potentiation - drug effects
Male
Memory
Memory - physiology
NMDA
Perirhinal cortex
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Rats
Rats, Sprague-Dawley
Time Factors
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Summary:Brief high frequency tetanization trains reliably induced input-specific long-term potentiation (LTP) in slices of rat perirhinal cortex maintained in vitro. Furthermore, associative interactions between inputs were observed following simultaneous tetanization of separate inputs. This associativity may be mediated via NMDA receptors as LTP was blocked in the presence of APV. These results suggest that LTP may underlie the participation of perirhinal cortex in memory processes.
ISSN:0006-8993
1872-6240
DOI:10.1016/0006-8993(96)00789-5