Functional diversity of helper T lymphocytes

The existence of subsets of CD4 + helper T lymphocytes that differ in their cytokine secretion patterns and effector functions provides a framework for understanding the heterogeneity of normal and pathological immune responses. Defining the cellular and molecular mechanisms of helper-T-cell differe...

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Bibliographic Details
Published in:Nature (London) 1996-10, Vol.383 (6603), p.787-793
Main Authors: Abbas, Abul K, Murphy, Kenneth M, Sher, Alan
Format: Article
Language:English
Subjects:
Animals
Autoimmunity - immunology
Biological and medical sciences
Cell differentiation
Cell Differentiation - genetics
Cytokines - biosynthesis
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Heterogeneity
Humanities and Social Sciences
Humans
Hypersensitivity - immunology
Immunity (Disease)
Immunobiology
Infection - immunology
Lymphocytes
Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation
Molecular biology
multidisciplinary
Pathology
Prophylaxis
review-article
Science
Science (multidisciplinary)
Self Tolerance - immunology
T-Lymphocyte Subsets - cytology
T-Lymphocyte Subsets - immunology
T-Lymphocytes, Helper-Inducer - cytology
T-Lymphocytes, Helper-Inducer - immunology
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Summary:The existence of subsets of CD4 + helper T lymphocytes that differ in their cytokine secretion patterns and effector functions provides a framework for understanding the heterogeneity of normal and pathological immune responses. Defining the cellular and molecular mechanisms of helper-T-cell differentiation should lead to rational strategies for manipulating immune responses for prophylaxis and therapy.
ISSN:0028-0836
1476-4687
DOI:10.1038/383787a0