Precisely correlated firing in cells of the lateral geniculate nucleus

• Published in: Nature (London) 1996-10, Vol.383 (6603), p.815-819
• Main Authors: Alonso, Jose-Manuel, Usrey, W. Martin, Reid, R. Clay
• Format: Article
• Language: English
• Subjects: Action Potentials; Animals; Biological and medical sciences; Cats; Central nervous system; Electrophysiology; Eyes & eyesight; Fundamental and applied biological sciences. Psychology; Geniculate Bodies - cytology; Geniculate Bodies - physiology; Humanities and Social Sciences; letter; multidisciplinary; Neural Pathways - physiology; Neurology; Neurons; Neurons - physiology; Science; Science (multidisciplinary); Thalamus - physiology; Vertebrates: nervous system and sense organs; Visual Cortex - physiology
• ISSN: 0028-0836; 1476-4687
• DOI: 10.1038/383815a0

SIMPLE cells within layer IV of the cat primary visual cortex are selective for lines of a specific orientation. It has been proposed that their receptive-field properties are established by the pattern of connections that they receive from the lateral geniculate nucleus (LGN) of the thalamus 1–5 . Thalamic inputs, however, represent only a small proportion of the synapses made onto simple cells 6–8 , and others have argued that corticocortical connections are likely to be important in shaping simple-cell response properties 9–11 . Here we describe a mechanism that might be involved in selectively strengthening the effect of thalamic inputs. We show that neighbouring geniculate neurons with overlapping receptive fields of the same type ( on -centre or off -centre) often fire spikes that are synchronized to within 1 millisecond. Moreover, these neurons often project to a common cortical target neuron where synchronous spikes are more effective in evoking a postsynaptic response. We propose that precisely correlated firing within a group of geniculate neurons could serve to reinforce the thalamic input to cortical simple cells.