Bone Morphogenetic Proteins Promote Astroglial Lineage Commitment by Mammalian Subventricular Zone Progenitor Cells

The epigenetic signals that regulate lineage development in the embryonic mammalian brain are poorly understood. Here we demonstrate that a specific subclass of the transforming growth factor β superfamily, the bone morphogenetic proteins (BMPs), cause the selective, dose-dependent elaboration of th...

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 1996-10, Vol.17 (4), p.595-606
Main Authors: Gross, Robert E, Mehler, Mark F, Mabie, Peter C, Zang, Ziying, Santschi, Linda, Kessler, John A
Format: Article
Language:English
Subjects:
Animals
Astrocytes - cytology
Astrocytes - drug effects
Astrocytes - physiology
Biomarkers
Bone Morphogenetic Protein Receptors
Bone Morphogenetic Proteins - pharmacology
Cell Differentiation - drug effects
Cells, Cultured
Corpus Striatum - cytology
Corpus Striatum - embryology
Embryo, Mammalian
Epidermal Growth Factor - pharmacology
Glial Fibrillary Acidic Protein - analysis
Kinetics
Mammalia
Mammals
Mice
Neurons - cytology
Oligodendroglia - drug effects
Receptors, Cell Surface - physiology
Receptors, Growth Factor
Signal Transduction
Stem Cells - cytology
Stem Cells - drug effects
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Summary:The epigenetic signals that regulate lineage development in the embryonic mammalian brain are poorly understood. Here we demonstrate that a specific subclass of the transforming growth factor β superfamily, the bone morphogenetic proteins (BMPs), cause the selective, dose-dependent elaboration of the astroglial lineage from murine embryonic subventricular zone (SVZ) multipotent progenitor cells. The astroglial inductive effect is characterized by enhanced morphological complexity and expression of glial fibrillary acidic protein, with concurrent suppression of neuronal and oligodendroglial cell fates. SVZ progenitor cells express transcripts for the appropriate BMP-specific type I and II receptor subunits and selective BMP ligands, suggesting the presence of paracrine or autocrine developmental signaling pathways (or both). These observations suggest that the BMPs have a selective role in determining the cell fate of SVZ multipotent progenitor cells or their more developmentally restricted progeny.
ISSN:0896-6273
1097-4199
DOI:10.1016/S0896-6273(00)80193-2