Selective Elevation of Monocyte Chemotactic Protein-1 in the Cerebrospinal Fluid of AIDS Patients with Cytomegalovirus Encephalitis

The CC chemokine monocyte chemotactic protein-1 (MCP-1) was markedly elevated in the cerebrospinal fluid (CSF) of human immunodeficiency virus (HIV)-infected patients with cytomegalovirus (CMV) encephalitis. The MCP-l CSF levelsin CMVencephalitis weremarkedly higher than those in the CSF of HIV-infe...

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Bibliographic Details
Published in:The Journal of infectious diseases 1996-11, Vol.174 (5), p.1098-1100
Main Authors: Bernasconi, Sergio, Cinque, Paola, Peri, Giuseppe, Sozzani, Silvano, Crociati, Anna, Torri, Walter, Vicenzi, Elisa, Vago, Luca, Lazzarin, Adriano, Poli, Guido, Mantovani, Alberto
Format: Article
Language:English
Subjects:
AIDS
AIDS-Related Opportunistic Infections - cerebrospinal fluid
AIDS/HIV
Biological and medical sciences
Central nervous system
Cerebrospinal fluid
Chemokine CCL2 - cerebrospinal fluid
Concise Communications
Cytomegalovirus
Cytomegalovirus Infections - cerebrospinal fluid
Encephalitis
Encephalitis, Viral - cerebrospinal fluid
HIV
HIV infections
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Infections
Medical sciences
Monocytes
Nervous system diseases
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Summary:The CC chemokine monocyte chemotactic protein-1 (MCP-1) was markedly elevated in the cerebrospinal fluid (CSF) of human immunodeficiency virus (HIV)-infected patients with cytomegalovirus (CMV) encephalitis. The MCP-l CSF levelsin CMVencephalitis weremarkedly higher than those in the CSF of HIV-infected patients with or without unrelated neurologic diseases, including progressivemultifocal leukoencephalopathy, cryptococcalmeningitis, toxoplasmic encephalitis, and primary lymphoma. Interleukin-8, RANTES, macrophage inflammatory protein (MIP)-1α, and MIP-1β were not substantially increased in the CSF of CMV encephalitis patients. High levels of MCP-1 may underlie monocyte recruitment and tissue damage in CMV encephalitis and may represent a rapid and useful tool in the diagnostic armamentarium for neurologic disorders associated with HIV infection.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/174.5.1098