Tc-99m Diphosphonate Uptake in Malignant Fibrous Histiocytoma: A Possible Iron-Related Effect

A man with malignant fibrous histiocytoma of the thigh had avid uptake of Tc-99m MDP in the lesion. Review of tissue sections showed considerable accumulation of iron in the tumor. Iron is known to be a potential nidus for deposition of the Tc-99m diphosphonates. A review was made of tissue sections...

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Bibliographic Details
Published in:Clinical nuclear medicine 1988-10, Vol.13 (10), p.734-735
Main Authors: SPENCER, RICHARD P, EVANS, DAVID D, FOROUHAR, FARIPOUR, FETTERS, DAVID V, YEH, SAMUEL D.J
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Dermatology
Hemosiderin - analysis
Histiocytoma, Benign Fibrous - analysis
Histiocytoma, Benign Fibrous - diagnostic imaging
Humans
Male
Medical sciences
Radionuclide Imaging
Soft Tissue Neoplasms - analysis
Soft Tissue Neoplasms - diagnostic imaging
Technetium Tc 99m Medronate
Thigh
Tumors of the skin and soft tissue. Premalignant lesions
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Summary:A man with malignant fibrous histiocytoma of the thigh had avid uptake of Tc-99m MDP in the lesion. Review of tissue sections showed considerable accumulation of iron in the tumor. Iron is known to be a potential nidus for deposition of the Tc-99m diphosphonates. A review was made of tissue sections from two other reported cases of malignant fibrous histiocytoma which also had significant accumulation of Tc-99m diphosphonates. Both revealed iron within the tumor. The origin of the iron is unknown (perhaps from necrosis and hemorrhage, from trauma, or from innate phagocytic activity of the histiocytes). However, this observation may serve as a stimulus to studies attempting to discern the underlying mechanisms of extraosseous deposition of the Tc-99m diphosphonates.
ISSN:0363-9762
1536-0229
DOI:10.1097/00003072-198810000-00011