Preliminary Imaging Results Using In-111 Labeled CYT-356 (Prostascintst) in the Detection of Recurrent Prostate Cancer

To evaluate whether In-111 capromab pendetide (an antibody conjugate directed to a glycoprotein found primarily on the cell membrane of prostate tissue) radioimmunoscintigraphy can localize residual or metastatic prostatic carcinoma in 15 patients after prostatectomy and lymphadenectomy for prostati...

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Bibliographic Details
Published in:Clinical nuclear medicine 1996-10, Vol.21 (10), p.759-767
Main Authors: SODEE, D BRUCE, CONANT, RIDGELY, CHALFANT, MARSHALL, MIRON, STEFAN, KLEIN, ERIC, BAHNSON, ROBERT, SPIRNAK, J PATRICK, CARLIN, BRUCE, BELLON, ERROL M, ROGERS, BARBARA
Format: Article
Language:English
Subjects:
Antibodies, Monoclonal
Biological and medical sciences
Female
Humans
Indium Radioisotopes
Investigative techniques, diagnostic techniques (general aspects)
Magnetic Resonance Imaging
Male
Medical sciences
Neoplasm Metastasis
Neoplasm Recurrence, Local - diagnostic imaging
Neoplasm Recurrence, Local - pathology
Prostate-Specific Antigen - blood
Prostatic Neoplasms - diagnostic imaging
Prostatic Neoplasms - pathology
Radionuclide Imaging
Radionuclide investigations
Tomography, X-Ray Computed
Urinary system
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Summary:To evaluate whether In-111 capromab pendetide (an antibody conjugate directed to a glycoprotein found primarily on the cell membrane of prostate tissue) radioimmunoscintigraphy can localize residual or metastatic prostatic carcinoma in 15 patients after prostatectomy and lymphadenectomy for prostatic carcinoma with rising serum prostate-specific antigen. One patient with 0.6 ng/ml serum prostate-specific antigen had normal imaging results and 14 patients had scintigraphic evidence of residual prostatic bed or metastatic prostatic carcinoma. Two patients with borderline abnormal bone scans had abnormal activity in the same regions on In-111 capromab pendetide images. All patients had negative radiographic abdominal and pelvic cross-sectional prestudy images, and there were no adverse effects related to In-111 capromab pendetide infusion and little human antimouse antibody response.
ISSN:0363-9762
1536-0229
DOI:10.1097/00003072-199610000-00002