Levels of 7α-hydroxy-4-cholesten-3-one in plasma reflect rates of bile acid synthesis in man

A method for analysis of 7α-hydroxy-4-cholesten-3-one in plasma is described. Following solid-phase extraction/purification the compound is determined by high-performance liquid chromatography using a UV detector. The median concentration in healthy subjects was 12 ng/ml (range 3–40). The levels wer...

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Bibliographic Details
Published in:FEBS letters 1988-11, Vol.239 (2), p.324-328
Main Authors: Axelson, M., Aly, A., Sjövall, J.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Bile acid synthesis
Bile Acids and Salts - biosynthesis
Biomarkers - blood
Cholestenes - blood
Cholestenones - blood
Cholestyramine Resin - therapeutic use
Chromatography, High Pressure Liquid
Female
HPLC
Human plasma
Humans
Intestinal Diseases - blood
Liver Diseases - blood
Male
Middle Aged
Solid-phase extraction
Sterol metabolism
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Description
Summary:A method for analysis of 7α-hydroxy-4-cholesten-3-one in plasma is described. Following solid-phase extraction/purification the compound is determined by high-performance liquid chromatography using a UV detector. The median concentration in healthy subjects was 12 ng/ml (range 3–40). The levels were lower in diseases associated with a low bile acid production: extrahepatic cholestasis,
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(88)80944-X