Receptor inactivation by dye-neuropeptide conjugates: 1. The synthesis of Cys-containing dye-neuropeptide conjugates

In an attempt to artenuate specifically identified receptors through photolysis, a four-step synthesis of a useful tethered derivative of Azure-B (Az) was developed. After characterization, this derivative was covalently attached to CFMRFamide, CFMRF, and CLRFamide (i.e., three different neuropeptid...

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Bibliographic Details
Published in:Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1996, Vol.17 (6), p.991-994
Main Authors: Feigenbaum, Jeffery J., Choubal, Milind D., Payza, Kemal, Kanofsky, Jeffrey R., Crumrine, David S.
Format: Article
Language:English
Subjects:
Azure Stains - chemistry
Azure-B
Cys-containing neuropeptide
Cysteine - chemistry
Dye
Dye-neuropeptide conjugate
FMRFamide
FMRFamide analogue
Neuropeptides - chemistry
Receptor inactivation
Receptors, Invertebrate Peptide - antagonists & inhibitors
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Summary:In an attempt to artenuate specifically identified receptors through photolysis, a four-step synthesis of a useful tethered derivative of Azure-B (Az) was developed. After characterization, this derivative was covalently attached to CFMRFamide, CFMRF, and CLRFamide (i.e., three different neuropeptide analogues of the putative neurotransmitter FMRFamide. This resulted in the formation of three dye-neuropeptide conjugates: Az-CFMRFamide, Az-CFMRF, and Az-CLRFamide.
ISSN:0196-9781
1873-5169
DOI:10.1016/0196-9781(96)00167-2