The role of angiotensin II in ingestive behaviour: A brief review of angiotensin II, thirst and Na appetite

From the outset, the study of angiotensin II (Ang II) in body fluid homeostasis has been both complicated and intriguing. Since the publication of an early report of the dipsogenic action of this peptide, the pursuit of the role of Ang II in thirst and Na appetite has continued for the last 25 years...

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Bibliographic Details
Published in:Regulatory peptides 1996-10, Vol.66 (1), p.73-81
Main Authors: Weisinger, R.S., Blair-West, J.R., Burns, P., Denton, D.A., McKinley, M.J., Tarjan, E.
Format: Article
Language:English
Subjects:
Angiotensin II
Angiotensin II - administration & dosage
Angiotensin II - physiology
Angiotensin receptor antagonist
Animals
Appetite - physiology
AT1
AT2
Captopril
Converting enzyme inhibitor
Drinking - physiology
Losartan
Sodium appetite
Sodium Chloride, Dietary - administration & dosage
Thirst
Thirst - physiology
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Summary:From the outset, the study of angiotensin II (Ang II) in body fluid homeostasis has been both complicated and intriguing. Since the publication of an early report of the dipsogenic action of this peptide, the pursuit of the role of Ang II in thirst and Na appetite has continued for the last 25 years. This pursuit captured the attention of all workers interested in the behavioural/physiological regulation of body fluid balance, with major contributions being made by James T. Fitzsimons and his colleagues. In spite of its powerful dipsogenic actions, delineation of its precise role in physiological thirst has been elusive and difficult to demonstrate. The influence of Ang II on Na intake took longer to show convincingly. However, in contrast to thirst, the role of Ang II in physiological Na appetite has been demonstrated clearly. The technological advances made during the recent years have greatly increased our ability to delineate the neurobiological context of Ang II-mediated responses. Thus, the future is promising in regard to illuminating the subtleties of the role of Ang II in body fluid balance.
ISSN:0167-0115
1873-1686
DOI:10.1016/0167-0115(96)00052-3