Presenilin 1 mRNA expression in hippocampi of sporadic Alzheimer's disease patients

Missense mutations in presenilin 1 ( PSNL 1) are known to cause familial Alzheimer's disease which is a subtype of Alzheimer's disease (AD). Our investigation, using an in situ hybridization technique, indicated that the localization of PNSL1 mRNA is similar in sporadic AD affected and nor...

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Bibliographic Details
Published in:Neuroscience research 1996-09, Vol.26 (1), p.75-78
Main Authors: Nishiyama, Kazutoshi, Murayama, Shigeo, Suzuki, Takashi, Mitsui, Yuko, Sakaki, Yoshiyuki, Kanazawa, Ichiro
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Alzheimer Disease - genetics
Alzheimer Disease - pathology
Alzheimer's disease
Autoradiography
DNA, Antisense
Family Health
Hippocampus
Hippocampus - metabolism
Hippocampus - pathology
Humans
In Situ Hybridization
Membrane Proteins - genetics
Middle Aged
mRNA
Neurofibrillary tangle
Neurofibrillary Tangles - genetics
Neurofibrillary Tangles - metabolism
Neurofilament Proteins - genetics
Polymerase Chain Reaction
Presenilin 1
RNA, Messenger - metabolism
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Summary:Missense mutations in presenilin 1 ( PSNL 1) are known to cause familial Alzheimer's disease which is a subtype of Alzheimer's disease (AD). Our investigation, using an in situ hybridization technique, indicated that the localization of PNSL1 mRNA is similar in sporadic AD affected and normal human brains. Furthermore, the amounts of PSNL1 mRNA in neurofibrillary tangle (NFT)-bearing neurons and those without NFTs did not differ, and the clinical severity of AD was not related to PSNL1 mRNA expression level.
ISSN:0168-0102
1872-8111
DOI:10.1016/0168-0102(96)01072-3