Review : Pneumothorax in patients with AIDS-related Pneumocystis carinii pneumonia

• Published in: The American journal of the medical sciences 1996-11, Vol.312 (5), p.229-234
• Main Authors: PASTORES, S. M, GARAY, S. M, NAIDICH, D. P, ROM, W. N
• Format: Article
• Language: English
• Subjects: Adult; AIDS-Related Opportunistic Infections - complications; AIDS/HIV; Biological and medical sciences; Female; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Male; Medical sciences; Pneumonia, Pneumocystis - complications; Pneumothorax - etiology; Respiration, Artificial - adverse effects; Retrospective Studies
• ISSN: 0002-9629; 1538-2990
• DOI: 10.1097/00000441-199611000-00008

A retrospective review was performed to describe the clinical characteristics, course, and outcome of pneumothorax for all patients admitted to Bellevue Hospital, New York, with AIDS who had Pneumocystis carinii pneumonia (PCP) diagnosed between January 1985, through July 1991. Of 1360 patients with AIDS and PCP, 67 patients (4.9%) were identified with pneumothorax; a group of 50 is the subject of this review. Of these 50 patients, 22 patients (44%) developed spontaneous pneumothorax, 15 patients (30%) developed pneumothorax during mechanical ventilation, and 13 patients (26%) had pneumothorax after an invasive procedure. Of the 22 patients with spontaneous pneumothorax, 8 had cystic parenchymal abnormalities on the chest radiograph and 6 had a history of PCP. The majority of patients were treated with tube thoracostomy and/or surgical intervention. All 15 patients who developed pneumothorax during mechanical ventilation died. Results of pathologic studies revealed varying degrees of interstitial inflammation and fibrosis interspersed with areas of hemorrhage and necrosis, and presence of P carinii cysts. Autopsy specimens obtained in two cases demonstrated multiple parenchymal cavities and evidence of an alveolar eosinophilic exudate with P carinii organisms. Spontaneous pneumothorax in patients with AIDS usually occurs in association with PCP and is associated with significant morbidity. Patients at risk include those with cystic lesions on chest radiograph and those patients with a history of PCP. Patients with AIDS and PCP who develop pneumothorax during mechanical ventilation have a poor outcome.