Experimental prevention of hypoxic pulmonary hypertension in animals by drugs

The rat model of chronic hypoxic pulmonary hypertension has been extensively studied and shows many of the features seen in man with chronic pulmonary hypertension. The development and reversibility of these changes by various treatments and by drugs is discussed. The experimental model may provide...

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Bibliographic Details
Published in:European heart journal 1988-09, Vol.9 (suppl-J), p.13-18
Main Authors: Suggett, A. J., Barer, G. R.
Format: Article
Language:English
Subjects:
Animals
Chronic hypoxia
Disease Models, Animal
drugs
Humans
Hypertension, Pulmonary - drug therapy
Hypertension, Pulmonary - etiology
Hypertension, Pulmonary - prevention & control
Hypoxia - complications
oxygen
pulmonary hypertension
Rats
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Summary:The rat model of chronic hypoxic pulmonary hypertension has been extensively studied and shows many of the features seen in man with chronic pulmonary hypertension. The development and reversibility of these changes by various treatments and by drugs is discussed. The experimental model may provide valuable clues as to the mechanisms involved in the aetiology of pulmonary hypertension in man.
ISSN:0195-668X
1522-9645
DOI:10.1093/eurheartj/9.suppl_J.13