Antibody Response of the Newborn After Herpes Simplex Virus Infection

Antibody responses to herpes simplex virus (HSV) types 1and 2, as determined by enzyme-linked immunoabsorbent assay (ELISA), neutralization, and immunoblot, were assessed in sera from newborns with documented HSV infections. The antibody response of the newborns was defined by disease duration and c...

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Bibliographic Details
Published in:The Journal of infectious diseases 1988-11, Vol.158 (5), p.925-933
Main Authors: Kahlon, Jasbir, Whitley, Richard J.
Format: Article
Language:English
Subjects:
Antibodies
Antibodies, Viral - biosynthesis
Antibody formation
Biological and medical sciences
Central nervous system diseases
Enzyme linked immunosorbent assay
Health outcomes
Herpes Simplex - immunology
Human viral diseases
Humans
Immediate-Early Proteins
Immunoblotting
Immunoglobulin G - biosynthesis
Immunoglobulin M - biosynthesis
Infant, Newborn
Infections
Infectious diseases
Medical sciences
Neonatal diseases
Nervous system diseases
Neutralization Tests
Newborns
Original Articles
Peptides - immunology
Simplexvirus
Simplexvirus - immunology
Viral diseases
Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye
Viral Proteins - immunology
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Summary:Antibody responses to herpes simplex virus (HSV) types 1and 2, as determined by enzyme-linked immunoabsorbent assay (ELISA), neutralization, and immunoblot, were assessed in sera from newborns with documented HSV infections. The antibody response of the newborns was defined by disease duration and correlated with disease classification and outcome. Three unique observations were made. First, the quantity of total antibodies at presentation, as determined by ELISA and neutralization, was not predictive of disease classification or outcome. Second, the frequency and intensity of antibody responses to immunologically recognized HSV polypeptides in newborns with central nervous system and disseminated infections were greater than those in newborns with infections localized to the skin, eye, and mouth. Third, the long-term outcome in HSV-infected newborns could be predicted by the quantity of antibodies to the immediate-early infected cell polypeptide ICP 4. These data provide insight into host response to individual polypeptides and their potential value in predicting long-term prognosis.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/158.5.925