The Pharmacodynamics of 6-(3-Dimethylaminopropionyl)forskolin and a Possible Metabolite in Beagles

A specific gas chromatography/mass spectroscopy method with a detection limit of 0.1ng/mL was developed for the measurement of 6-(3-dimethylaminopropionyl)forskolin (1) in beagle plasma. Using this method, plasma concentrations of 1 in beagles given pharmacologically effective intravenous doses of 1...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1996-04, Vol.85 (4), p.377-380
Main Authors: Kametani, Shunichi, Matsumoto, Shinichi, Takahira, Takashi, Hosono, Makoto, Hashimoto, Yutaka, Horinishi, Hiroo
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blood Pressure - drug effects
Cardiovascular system
Colforsin - analogs & derivatives
Colforsin - pharmacokinetics
Colforsin - pharmacology
Dogs
Heart Rate - drug effects
Hemodynamics - drug effects
Infusions, Intravenous
Injections, Intravenous
Medical sciences
Miscellaneous
Pharmacology. Drug treatments
Stimulation, Chemical
Vasodilator Agents - pharmacokinetics
Vasodilator Agents - pharmacology
Ventricular Pressure - drug effects
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Summary:A specific gas chromatography/mass spectroscopy method with a detection limit of 0.1ng/mL was developed for the measurement of 6-(3-dimethylaminopropionyl)forskolin (1) in beagle plasma. Using this method, plasma concentrations of 1 in beagles given pharmacologically effective intravenous doses of 1·HCl were determined. The observed maximal plasma concentrations rapidly decreased with time, and half-lives of the α-phases were
ISSN:0022-3549
1520-6017
DOI:10.1021/js930234z