Peptide regulation of intestinal glucose absorption

Terminal hydrolysis of oligosaccharides at the small intestinal brush border yields monomeric glucose, most of which is then absorbed by the transepithelial route. This involves carrier-mediated processes requiring specialized functional proteins situated in the brush border (SGLT1) and basolateral...

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Bibliographic Details
Published in:Journal of animal science 1996-10, Vol.74 (10), p.2523-2540
Main Authors: Bird, A.R. (CSIRO, Adelaide, Australia.), Croom, W.J. Jr, Fan, Y.K, Black, B.L, McBride, B.W, Taylor, I.L
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
CONTROL HORMONAL
CONTROLE HORMONAL
Epidermal Growth Factor - physiology
Fundamental and applied biological sciences. Psychology
GLUCOSA
GLUCOSE
Glucose - pharmacokinetics
INJECTION
INTESTIN
Intestinal Absorption - physiology
Intestine. Mesentery
INTESTINOS
INYECCION
MAMIFEROS
MAMMIFERE
MEMBRANA MUCOSA
Monosaccharide Transport Proteins - chemistry
Monosaccharide Transport Proteins - physiology
MUQUEUSE
PEPTIDE
Peptide YY
Peptides - physiology
PEPTIDOS
PROMOTEUR DE CROISSANCE ANIMALE
PROMOTORES DEL CRECIMIENTO ANIMAL
RATON
Ruminants - physiology
SOMATOSTATINA
SOMATOSTATINE
SOURIS
TRANSPORT DES SUBSTANCES NUTRITIVES
TRANSPORTE DE NUTRIENTES
Vertebrates: digestive system
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Description
Summary:Terminal hydrolysis of oligosaccharides at the small intestinal brush border yields monomeric glucose, most of which is then absorbed by the transepithelial route. This involves carrier-mediated processes requiring specialized functional proteins situated in the brush border (SGLT1) and basolateral (GLUT2) membranes. Glucose translocation at the enterocyte apical membrane is an active, Na+-dependent and saturable process, whereas exit from enterocytes is by facilitated diffusion and is energy-independent. Specific adaptation of glucose active transport occurs in response to changes in the proportion of glucose in the diet. The regulatory signals responsible for transport induction are imprecisely defined, although numerous protein hormone and gut regulatory proteins are implicated. Epidermal growth factor and peptide YY invoke up-regulation a jejunal active glucose transport in vivo. Recently, peptide YY has been shown to stimulate active glucose transport in mice without altering oxygen consumption of jejunal tissue. Several other peptides whose presence in tissues of the small bowel imply that the exert control over epithelial nutrient transport are considered, and the relevance of these physiological manipulations, with various regulatory peptides an hormones, to animal agriculture are discussed
ISSN:0021-8812
1525-3163
0021-8812
DOI:10.2527/1996.74102523x