The Gln/Arg polymorphism of human paraoxonase (PON 192) is not related to myocardial infarction in the ECTIM Study

Paraoxonase is a high-density-lipoprotein associated enzyme capable of hydrolyzing lipid peroxides, which has been suggested to contribute to atherosclerosis and coronary heart disease (CHD). We studied the Gln/Arg polymorphism affecting codon 192 of human paraoxonase (PON 192) to determine whether...

Full description

Saved in:
Bibliographic Details
Published in:Atherosclerosis 1996-10, Vol.126 (2), p.299-303
Main Authors: Herrmann, Stefan-Martin, Blanc, Hervé, Poirier, Odette, Arveiler, Dominique, Luc, Gerald, Evans, Alun, Marques-Vidal, Pedro, Bard, Jean-Marie, Cambien, François
Format: Article
Language:English
Subjects:
Adult
Alleles
Aryldialkylphosphatase
Atherosclerosis
Biological and medical sciences
Cardiology. Vascular system
Coronary heart disease
Esterases - genetics
Esterases - metabolism
Genotype
Heart
Humans
Male
Medical sciences
Middle Aged
Myocardial infarction
Myocardial Infarction - blood
Myocardial Infarction - enzymology
Myocardial Infarction - genetics
Paraoxonase
Polymorphism
Polymorphism, Genetic
Risk Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Paraoxonase is a high-density-lipoprotein associated enzyme capable of hydrolyzing lipid peroxides, which has been suggested to contribute to atherosclerosis and coronary heart disease (CHD). We studied the Gln/Arg polymorphism affecting codon 192 of human paraoxonase (PON 192) to determine whether this polymorphism, which is associated with serum paraoxonase (PON) activity, represents a risk factor for myocardial infarction (MI). The PON 192 polymorphism was analysed in 642 male patients with myocardial infarction and 701 age-matched controls participating in the ECTIM Study (Etude Cas-Témoins de l'Infarctus du Myocarde). The frequency of the Gln allele was 0.69 in cases and 0.70 in controls (ns). The frequency of the PON 192/Arg allele in 405 MI patients who underwent coronary angiography was 0.295, 0.323 and 0.331, respectively in those with 1, 2 or 3 stenosed arteries (stenosis > 50%) (ns). The mean levels of several plasma lipids, lipoproteins and apolipoproteins were compared between the 3 PON genotypes and no difference was observed. The PON 192 polymorphism was unrelated to MI, the severity of coronary atherosclerosis and to plasma levels of several lipid variables.
ISSN:0021-9150
1879-1484
DOI:10.1016/0021-9150(96)05917-5