The Gln/Arg polymorphism of human paraoxonase (PON 192) is not related to myocardial infarction in the ECTIM Study

• Published in: Atherosclerosis 1996-10, Vol.126 (2), p.299-303
• Main Authors: Herrmann, Stefan-Martin, Blanc, Hervé, Poirier, Odette, Arveiler, Dominique, Luc, Gerald, Evans, Alun, Marques-Vidal, Pedro, Bard, Jean-Marie, Cambien, François
• Format: Article
• Language: English
• Subjects: Adult; Alleles; Aryldialkylphosphatase; Atherosclerosis; Biological and medical sciences; Cardiology. Vascular system; Coronary heart disease; Esterases - genetics; Esterases - metabolism; Genotype; Heart; Humans; Male; Medical sciences; Middle Aged; Myocardial infarction; Myocardial Infarction - blood; Myocardial Infarction - enzymology; Myocardial Infarction - genetics; Paraoxonase; Polymorphism; Polymorphism, Genetic; Risk Factors
• ISSN: 0021-9150; 1879-1484
• DOI: 10.1016/0021-9150(96)05917-5

Paraoxonase is a high-density-lipoprotein associated enzyme capable of hydrolyzing lipid peroxides, which has been suggested to contribute to atherosclerosis and coronary heart disease (CHD). We studied the Gln/Arg polymorphism affecting codon 192 of human paraoxonase (PON 192) to determine whether this polymorphism, which is associated with serum paraoxonase (PON) activity, represents a risk factor for myocardial infarction (MI). The PON 192 polymorphism was analysed in 642 male patients with myocardial infarction and 701 age-matched controls participating in the ECTIM Study (Etude Cas-Témoins de l'Infarctus du Myocarde). The frequency of the Gln allele was 0.69 in cases and 0.70 in controls (ns). The frequency of the PON 192/Arg allele in 405 MI patients who underwent coronary angiography was 0.295, 0.323 and 0.331, respectively in those with 1, 2 or 3 stenosed arteries (stenosis > 50%) (ns). The mean levels of several plasma lipids, lipoproteins and apolipoproteins were compared between the 3 PON genotypes and no difference was observed. The PON 192 polymorphism was unrelated to MI, the severity of coronary atherosclerosis and to plasma levels of several lipid variables.