Tumour marker detection in oesophageal carcinoma

Levels of the tumour markers CEA, CA 19-9, CA 125 and SCC were measured in 58 patients presenting with oesophageal carcinoma and compared with levels in patients with benign oesophageal disease and levels in normal volunteers. CEA and CA 19-9 were significantly increased in the patients with oesopha...

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Bibliographic Details
Published in:European journal of surgical oncology 1996-10, Vol.22 (5), p.505-507
Main Authors: Mealy, K., Feely, J., Reid, I., McSweeney, J., Walsh, T., Hennessy, T.P.J.
Format: Article
Language:English
Subjects:
Adult
Aged
Antigens, Neoplasm - blood
Antigens, Tumor-Associated, Carbohydrate - blood
Biological and medical sciences
Biomarkers, Tumor - blood
CA-125 Antigen - blood
CA-19-9 Antigen - blood
Carcinoembryonic Antigen - blood
Carcinoma, Squamous Cell - blood
Carcinoma, Squamous Cell - therapy
Esophageal Neoplasms - blood
Esophageal Neoplasms - therapy
Esophagus
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Male
Medical sciences
Middle Aged
oesophageal carcinoma
Serpins
Survival Analysis
Tumors
tumour markers
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Summary:Levels of the tumour markers CEA, CA 19-9, CA 125 and SCC were measured in 58 patients presenting with oesophageal carcinoma and compared with levels in patients with benign oesophageal disease and levels in normal volunteers. CEA and CA 19-9 were significantly increased in the patients with oesophageal cancer, however, individual sensitivity for CEA, CA 19-9, CA 125 and SCC was only 28, 34, 10, and 32%, respectively. The combined sensitivity of all markers was 64% and specificity was 80%. There was no difference in combined tumour marker sensitivity between squamous or adenocarcinomas of the oesophagus. No consistent change in marker levels occurred with treatment, and tumour marker levels could not be significantly correlated with stage of disease or short-term survival. These results indicate that tumour marker sensitivity is too low for oesophageal cancer screening and has poor prognostic significance in those undergoing treatment.
ISSN:0748-7983
1532-2157
DOI:10.1016/S0748-7983(96)92998-4