Disruption of cell adhesion in Xenopus embryos by Pagliaccio, an Eph-class receptor tyrosine kinase

Pagliaccio (Pag) is a receptor tyrosine kinase of the Eph family that is expressed in Xenopus embryos in a diverse set of localized tissues. Pag is the Xenopus homolog of Hek-8 (human), Sek-1 (mouse), cek8 (chicken), and RTK-1 (zebrafish). We have investigated the function of this protein by injecti...

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Bibliographic Details
Published in:Developmental biology 1996-11, Vol.179 (2), p.309-319
Main Authors: Winning, R S, Scales, J B, Sargent, T D
Format: Article
Language:English
Subjects:
Animals
Cell Adhesion - genetics
Embryo, Nonmammalian - cytology
Embryo, Nonmammalian - metabolism
Gene Expression Regulation, Developmental
Receptor Protein-Tyrosine Kinases - biosynthesis
Receptor Protein-Tyrosine Kinases - genetics
RNA - analysis
Xenopus - embryology
Xenopus - metabolism
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Summary:Pagliaccio (Pag) is a receptor tyrosine kinase of the Eph family that is expressed in Xenopus embryos in a diverse set of localized tissues. Pag is the Xenopus homolog of Hek-8 (human), Sek-1 (mouse), cek8 (chicken), and RTK-1 (zebrafish). We have investigated the function of this protein by injecting RNA encoding an epidermal growth factor receptor-Pag chimera into early Xenopus embryos. Activation of the chimeric receptor results in a kinase-dependent loss of cell-cell adhesion. This dissociation can be reversed by co-injection of RNA encoding C-cadherin, suggesting that one or more cadherins could be the functional targets for Pag activity.
ISSN:0012-1606
DOI:10.1006/dbio.1996.0262