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Preoperative Value of CA 125 as a Reflection of Tumor Grade in Epithelial Ovarian Cancer

A retrospective study of 60 patients with invasive epithelial ovarian cancer was conducted. The significance of preoperative serum CA 125 level with respect to tumor grade and tumor stage was determined. Tumor grade bears a strong influence on the preoperative CA 125 level; the correlation is high a...

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Published in:	Gynecologic oncology 1996-11, Vol.63 (2), p.166-172
Main Authors:	But, Igor, Gorišek, Borut
Format:	Article
Language:	English
Subjects:	Adenocarcinoma, Mucinous - blood Adenocarcinoma, Mucinous - immunology Adenocarcinoma, Mucinous - pathology Adult Aged Aged, 80 and over Biological and medical sciences CA-125 Antigen - blood Carcinoma - blood Carcinoma - immunology Carcinoma - pathology Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Medical sciences Middle Aged Neoplasm Proteins - blood Neoplasm Staging Ovarian Neoplasms - blood Ovarian Neoplasms - immunology Ovarian Neoplasms - pathology Retrospective Studies Tumors
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container_title	Gynecologic oncology
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creator	But, Igor Gorišek, Borut
description	A retrospective study of 60 patients with invasive epithelial ovarian cancer was conducted. The significance of preoperative serum CA 125 level with respect to tumor grade and tumor stage was determined. Tumor grade bears a strong influence on the preoperative CA 125 level; the correlation is high and statistically significant (r= 0.74,P< 0.01). The influence of FIGO stage on preoperative CA 125 level is also significant (r= 0.51,P< 0.01), but the results of the multivariate analysis show that the influence of tumor grade on preoperative CA 125 level is stronger (P< 0.01). It is believed that tumor grade is the decisive factor dictating the level of CA 125 in a certain stage of the disease and so influences the preoperative CA 125 level. It is also believed that low preoperative antigen levels of well-differentiated ovarian carcinomas in FIGO stage I are the cause of poor sensitivity of the CA 125 test, thus limiting its applicability for screening purposes.
doi_str_mv	10.1006/gyno.1996.0301
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The significance of preoperative serum CA 125 level with respect to tumor grade and tumor stage was determined. Tumor grade bears a strong influence on the preoperative CA 125 level; the correlation is high and statistically significant (r= 0.74,P< 0.01). The influence of FIGO stage on preoperative CA 125 level is also significant (r= 0.51,P< 0.01), but the results of the multivariate analysis show that the influence of tumor grade on preoperative CA 125 level is stronger (P< 0.01). It is believed that tumor grade is the decisive factor dictating the level of CA 125 in a certain stage of the disease and so influences the preoperative CA 125 level. It is also believed that low preoperative antigen levels of well-differentiated ovarian carcinomas in FIGO stage I are the cause of poor sensitivity of the CA 125 test, thus limiting its applicability for screening purposes.</description><identifier>ISSN: 0090-8258</identifier><identifier>EISSN: 1095-6859</identifier><identifier>DOI: 10.1006/gyno.1996.0301</identifier><identifier>PMID: 8910622</identifier><identifier>CODEN: GYNOA3</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Adenocarcinoma, Mucinous - blood ; Adenocarcinoma, Mucinous - immunology ; Adenocarcinoma, Mucinous - pathology ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; CA-125 Antigen - blood ; Carcinoma - blood ; Carcinoma - immunology ; Carcinoma - pathology ; Female ; Female genital diseases ; Gynecology. Andrology. Obstetrics ; Humans ; Medical sciences ; Middle Aged ; Neoplasm Proteins - blood ; Neoplasm Staging ; Ovarian Neoplasms - blood ; Ovarian Neoplasms - immunology ; Ovarian Neoplasms - pathology ; Retrospective Studies ; Tumors</subject><ispartof>Gynecologic oncology, 1996-11, Vol.63 (2), p.166-172</ispartof><rights>1996 Academic Press</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-7ac4b564662d04b16bebf46809a4dd5bcf911e369d3afca0afb91fd3dd953e9c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2482772$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8910622$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>But, Igor</creatorcontrib><creatorcontrib>Gorišek, Borut</creatorcontrib><title>Preoperative Value of CA 125 as a Reflection of Tumor Grade in Epithelial Ovarian Cancer</title><title>Gynecologic oncology</title><addtitle>Gynecol Oncol</addtitle><description>A retrospective study of 60 patients with invasive epithelial ovarian cancer was conducted. The significance of preoperative serum CA 125 level with respect to tumor grade and tumor stage was determined. Tumor grade bears a strong influence on the preoperative CA 125 level; the correlation is high and statistically significant (r= 0.74,P< 0.01). The influence of FIGO stage on preoperative CA 125 level is also significant (r= 0.51,P< 0.01), but the results of the multivariate analysis show that the influence of tumor grade on preoperative CA 125 level is stronger (P< 0.01). It is believed that tumor grade is the decisive factor dictating the level of CA 125 in a certain stage of the disease and so influences the preoperative CA 125 level. It is also believed that low preoperative antigen levels of well-differentiated ovarian carcinomas in FIGO stage I are the cause of poor sensitivity of the CA 125 test, thus limiting its applicability for screening purposes.</description><subject>Adenocarcinoma, Mucinous - blood</subject><subject>Adenocarcinoma, Mucinous - immunology</subject><subject>Adenocarcinoma, Mucinous - pathology</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>CA-125 Antigen - blood</subject><subject>Carcinoma - blood</subject><subject>Carcinoma - immunology</subject><subject>Carcinoma - pathology</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Proteins - blood</subject><subject>Neoplasm Staging</subject><subject>Ovarian Neoplasms - blood</subject><subject>Ovarian Neoplasms - immunology</subject><subject>Ovarian Neoplasms - pathology</subject><subject>Retrospective Studies</subject><subject>Tumors</subject><issn>0090-8258</issn><issn>1095-6859</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><recordid>eNp1kEFr3DAQRkVpSDdpr70VdCi9eSPJtiwdw7JNAgsJISm9ibE0alW8livZC_n3sdklt5zm8L35mHmEfOVszRmTV39e-rjmWss1Kxn_QFac6bqQqtYfyYoxzQolavWJXOT8j7GFEefkXGnOpBAr8vshYRwwwRgOSH9BNyGNnm6uKRc1hUyBPqLv0I4h9kvyNO1jojcJHNLQ0-0Qxr_YBejo_QFSgJ5uoLeYPpMzD13GL6d5SZ5_bp82t8Xu_uZuc70rbCnVWDRgq7aWlZTCsarlssXWV1IxDZVzdWu95hxLqV0J3gID32ruXemcrkvUtrwkP469Q4r_J8yj2Ydsseugxzhl06iai0aJGVwfQZtizgm9GVLYQ3oxnJlFpVlUmkWlWTTNC99OzVO7R_eGn9zN-fdTDtlC59P8d8hvmKiUaJoFU0cMZwuHgMlkG3BW5EKatRoXw3sXvAKWx47Z</recordid><startdate>19961101</startdate><enddate>19961101</enddate><creator>But, Igor</creator><creator>Gorišek, Borut</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19961101</creationdate><title>Preoperative Value of CA 125 as a Reflection of Tumor Grade in Epithelial Ovarian Cancer</title><author>But, Igor ; Gorišek, Borut</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-7ac4b564662d04b16bebf46809a4dd5bcf911e369d3afca0afb91fd3dd953e9c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adenocarcinoma, Mucinous - blood</topic><topic>Adenocarcinoma, Mucinous - immunology</topic><topic>Adenocarcinoma, Mucinous - pathology</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>CA-125 Antigen - blood</topic><topic>Carcinoma - blood</topic><topic>Carcinoma - immunology</topic><topic>Carcinoma - pathology</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Proteins - blood</topic><topic>Neoplasm Staging</topic><topic>Ovarian Neoplasms - blood</topic><topic>Ovarian Neoplasms - immunology</topic><topic>Ovarian Neoplasms - pathology</topic><topic>Retrospective Studies</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>But, Igor</creatorcontrib><creatorcontrib>Gorišek, Borut</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gynecologic oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>But, Igor</au><au>Gorišek, Borut</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preoperative Value of CA 125 as a Reflection of Tumor Grade in Epithelial Ovarian Cancer</atitle><jtitle>Gynecologic oncology</jtitle><addtitle>Gynecol Oncol</addtitle><date>1996-11-01</date><risdate>1996</risdate><volume>63</volume><issue>2</issue><spage>166</spage><epage>172</epage><pages>166-172</pages><issn>0090-8258</issn><eissn>1095-6859</eissn><coden>GYNOA3</coden><abstract>A retrospective study of 60 patients with invasive epithelial ovarian cancer was conducted. The significance of preoperative serum CA 125 level with respect to tumor grade and tumor stage was determined. Tumor grade bears a strong influence on the preoperative CA 125 level; the correlation is high and statistically significant (r= 0.74,P< 0.01). The influence of FIGO stage on preoperative CA 125 level is also significant (r= 0.51,P< 0.01), but the results of the multivariate analysis show that the influence of tumor grade on preoperative CA 125 level is stronger (P< 0.01). It is believed that tumor grade is the decisive factor dictating the level of CA 125 in a certain stage of the disease and so influences the preoperative CA 125 level. It is also believed that low preoperative antigen levels of well-differentiated ovarian carcinomas in FIGO stage I are the cause of poor sensitivity of the CA 125 test, thus limiting its applicability for screening purposes.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>8910622</pmid><doi>10.1006/gyno.1996.0301</doi><tpages>7</tpages></addata></record>
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subjects	Adenocarcinoma, Mucinous - blood Adenocarcinoma, Mucinous - immunology Adenocarcinoma, Mucinous - pathology Adult Aged Aged, 80 and over Biological and medical sciences CA-125 Antigen - blood Carcinoma - blood Carcinoma - immunology Carcinoma - pathology Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Medical sciences Middle Aged Neoplasm Proteins - blood Neoplasm Staging Ovarian Neoplasms - blood Ovarian Neoplasms - immunology Ovarian Neoplasms - pathology Retrospective Studies Tumors
title	Preoperative Value of CA 125 as a Reflection of Tumor Grade in Epithelial Ovarian Cancer
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