The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

The protein Sonic hedgehog (Shh) controls patterning and growth during vertebrate development. Here we demonstrate that it binds Patched (vPtc), which has been identified as a tumour-suppressor protein in basal cell carcinoma, with high affinity. We show that Re can form a physical complex with a ne...

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Bibliographic Details
Published in:Nature (London) 1996-11, Vol.384 (6605), p.129-134
Main Authors: Stone, Donna M, Hynes, Mary, Armanini, Mark, Swanson, Todd A, Gu, Qimin, Johnson, Ronald L, Scott, Matthew P, Pennica, Diane, Goddard, Audrey, Phillips, Heidi, Noll, Markus, Hooper, Joan E, de Sauvage, Frederic, Rosenthal, Arnon
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Biological and medical sciences
Cell Line
Cloning, Molecular
COS Cells
Drosophila
Drosophila Proteins
Embryology: invertebrates and vertebrates. Teratology
Fundamental and applied biological sciences. Psychology
Genes, Tumor Suppressor
Hedgehog Proteins
Humanities and Social Sciences
Humans
Insect Hormones - genetics
Insect Hormones - metabolism
Intracellular Signaling Peptides and Proteins
Membrane Proteins - genetics
Membrane Proteins - metabolism
Mice
Molecular embryology
Molecular Sequence Data
multidisciplinary
Patched Receptors
Patched-1 Receptor
Proteins - genetics
Proteins - metabolism
Rats
Receptors, Cell Surface - genetics
Receptors, Cell Surface - metabolism
Receptors, G-Protein-Coupled
Science
Science (multidisciplinary)
Sequence Homology, Amino Acid
Smoothened Receptor
Tissue Distribution
Trans-Activators
Vertebrates
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Summary:The protein Sonic hedgehog (Shh) controls patterning and growth during vertebrate development. Here we demonstrate that it binds Patched (vPtc), which has been identified as a tumour-suppressor protein in basal cell carcinoma, with high affinity. We show that Re can form a physical complex with a newly cloned vertebrate homologue of the Drosophila protein Smoothened (vSmo), and that vSmo is coexpressed with vPtc in many tissues but does not bind Shh directly. These findings, combined with available genetic evidence from Drosophila , support the hypothesis that Ptc is a receptor for Shh, and that vSmo could be a signalling component that is linked to Ptc.
ISSN:0028-0836
1476-4687
DOI:10.1038/384129a0