Differential activation of STATs 3 and 5 during mammary gland development

We have investigated the activity of STAT family members throughout a mammary developmental cycle. Transcripts for Stat 5 were upregulated during pregnancy whilst STAT1 and STAT3 mRNAs were expressed at constant levels. DNA binding complexes containing both STAT5a and 5b showed differing affinities...

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Bibliographic Details
Published in:FEBS letters 1996-10, Vol.396 (1), p.77-80
Main Authors: Philp, Janet A.C., Burdon, Thomas G., Watson, Christine J.
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Apoptosis - genetics
Binding Sites
DNA-Binding Proteins - chemistry
DNA-Binding Proteins - genetics
DNA-Binding Proteins - metabolism
Female
Gene Expression Regulation, Developmental
Lactation
Lactoglobulins - genetics
Mammary gland
Mammary Glands, Animal - growth & development
Mammary Glands, Animal - metabolism
Mice
Milk Proteins
Pregnancy
Promoter Regions, Genetic
Protein Conformation
Signal transduction
STAT
STAT1 Transcription Factor
STAT3 Transcription Factor
STAT5 Transcription Factor
Trans-Activators - chemistry
Trans-Activators - genetics
Trans-Activators - metabolism
Transcription, Genetic
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Summary:We have investigated the activity of STAT family members throughout a mammary developmental cycle. Transcripts for Stat 5 were upregulated during pregnancy whilst STAT1 and STAT3 mRNAs were expressed at constant levels. DNA binding complexes containing both STAT5a and 5b showed differing affinities for two naturally occurring STAT5 binding sites. In the involuting mammary gland STAT5 activity decreased whereas STAT3 was specifically activated. These observations reveal a complex pattern of activation of STAT factors during mammary growth, differentiation and remodelling and provide the first evidence for the involvement of STAT3 in development of the mammary gland.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(96)01069-1