Unusual chromosome aberration, t(13;14)(q32;q32.3), in a case of essential thrombocythemia with extreme thrombocytosis

A case of essential thrombocythemia (ET) with extreme thrombocytosis in a 70-year-old male patient is described. The cytogenetic analysis revealed a pathologic clone with the following previously unreported, unusual karyotype: 46,XY,t(13;14)(q32;q32.3) and pericentric inversion of chromosome 9. The...

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Bibliographic Details
Published in:Cancer genetics and cytogenetics 1996-10, Vol.91 (1), p.68-70
Main Authors: Mitev, Lubomir, Georgiev, George, Petrov, Angel, Manolova, Yanka
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Chromosome Aberrations - genetics
Chromosome Inversion
Chromosomes, Human, Pair 13 - genetics
Chromosomes, Human, Pair 14 - genetics
Chromosomes, Human, Pair 9 - genetics
Hematologic and hematopoietic diseases
Humans
Karyotyping
Male
Medical sciences
Platelet diseases and coagulopathies
Thrombocythemia, Essential - complications
Thrombocythemia, Essential - genetics
Thrombocytosis - complications
Thrombocytosis - genetics
Translocation, Genetic - genetics
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Summary:A case of essential thrombocythemia (ET) with extreme thrombocytosis in a 70-year-old male patient is described. The cytogenetic analysis revealed a pathologic clone with the following previously unreported, unusual karyotype: 46,XY,t(13;14)(q32;q32.3) and pericentric inversion of chromosome 9. The possible association of t(13;14) with the high platelet count is discussed.
ISSN:0165-4608
1873-4456
DOI:10.1016/S0165-4608(96)00153-7